Proposition 65

Proposition 65, officially known as the Safe Drinking Water and Toxic Enforcement Act of 1986, was enacted as a ballot initiative in November 1986. The law protects the state's drinking water sources from being contaminated with chemicals known to cause cancer, birth defects or other reproductive harm, and requires businesses to inform Californians about exposures to such chemicals.

Proposition 65 requires the state to maintain and update the list of chemicals subject to the law’s requirements.

Questions about Proposition 65? Visit our Proposition 65 Warnings website.

Proposition 65 Resources

About Proposition 65

The Safe Drinking Water and Toxic Enforcement Act

The Proposition 65 List

The current Proposition 65 list is dated January 03, 2025

Meetings, Hearings and Workshops

Upcoming and past meetings, hearings and workshops

Notices

All Proposition 65 Notices

Laws and Regulations

Links and downloads related to Proposition 65 statute and regulations

Warnings

Visit this website to learn about warnings for exposures to chemicals on the Proposition 65 List

How chemicals are added to the Proposition 65 list

Learn how chemicals are added to the list

Safe Use Determinations

A Safe Use Determination (SUD) is a written statement issued by OEHHA, interpreting and applying Proposition 65 regulations to specific facts in response to a request by a business or trade group

Interpretive Guidelines for Proposition 65

An Interpretive Guideline interprets Proposition 65 regulations as applied to specific facts

Information Letters

Letters about Proposition 65's application from OEHHA to interested parties

Warning Regulations

Clear and reasonable warnings

Searchable Proposition 65 Chemical Database

Search the Proposition 65 Chemical Database

Safe harbor levels

Proposition 65 No Significant Risk Levels (NSRLs) and Maximum Allowable Dose Levels (MADLs)

Reports, Notices, Documents

October 25, 2013: Notice of Proposed Rulemaking, Title 27, California Code of Regulations,Proposed Amendment To Section 25302, Science Advisory Board and Section 25304, Financial Disclosure

These amendments would clarify the existing requirements for scientific experts appointed to the committees by the Governor. These amendments will also remove certain portions of Section 25304 that were made redundant when advisory committee members were added to the Office of Environmental Health Hazard Assessment’s (OEHHA) Conflict of Interest Code.

October 10, 2013: Withdrawal of Notice of Intent to Change the Basis for Listing as Known to the State of California to Cause Reproductive Toxicity: Hexafluoroacetone and Phenylphosphine

Withdrawal of the September 20, 2013 notice announcing the intention to change the basis for the listing of hexafluoroacetone (CAS No. 684-16-2) and phenylphosphine (CAS No. 638-21-1) as known to the state to cause reproductive toxicity

October 4, 2013: Hazard Identification Documents for Butyl Benzyl Phthalate and Diisononyl Phthalate (DINP) to be Considered at the December 5, 2013 CIC Meeting

Announcement of the Carcinogen Identification Committee meeting scheduled for December 5, 2013 and the availability of hazard identification documents for butyl benzyl phthalate and diisononyl phthalate.

September 27, 2013: Chemical Listed Effective September 27, 2013 as Known to the State of California to Cause Cancer: Chloramphenicol Sodium Succinate

Effective September 27, 2013, chloramphenicol sodium succinate is added to the list of chemicals known to the State to cause cancer for purposes of Proposition 65. The listing is based on the formally required to be labeled or identified mechanism.

September 20, 2013: Intent to Change the Basis for Listing as Known to the State of California to Cause Reproductive Toxicity: Hexafluoroacetone and Phenylphosphine

Intent to change the basis for the listing of hexafluoroacetone and phenylphosphine as known to the state to cause reproductive toxicity.