Proposition 65

Proposition 65, officially known as the Safe Drinking Water and Toxic Enforcement Act of 1986, was enacted as a ballot initiative in November 1986. The law protects the state's drinking water sources from being contaminated with chemicals known to cause cancer, birth defects or other reproductive harm, and requires businesses to inform Californians about exposures to such chemicals.

Proposition 65 requires the state to maintain and update the list of chemicals subject to the law’s requirements.

Questions about Proposition 65? Visit our Proposition 65 Warnings website.

Proposition 65 Resources

About Proposition 65

The Safe Drinking Water and Toxic Enforcement Act

The Proposition 65 List

The current Proposition 65 list is dated January 03, 2025

Meetings, Hearings and Workshops

Upcoming and past meetings, hearings and workshops

Notices

All Proposition 65 Notices

Laws and Regulations

Links and downloads related to Proposition 65 statute and regulations

Warnings

Visit this website to learn about warnings for exposures to chemicals on the Proposition 65 List

How chemicals are added to the Proposition 65 list

Learn how chemicals are added to the list

Safe Use Determinations

A Safe Use Determination (SUD) is a written statement issued by OEHHA, interpreting and applying Proposition 65 regulations to specific facts in response to a request by a business or trade group

Interpretive Guidelines for Proposition 65

An Interpretive Guideline interprets Proposition 65 regulations as applied to specific facts

Information Letters

Letters about Proposition 65's application from OEHHA to interested parties

Warning Regulations

Clear and reasonable warnings

Searchable Proposition 65 Chemical Database

Search the Proposition 65 Chemical Database

Safe harbor levels

Proposition 65 No Significant Risk Levels (NSRLs) and Maximum Allowable Dose Levels (MADLs)

Reports, Notices, Documents

December 4, 2015: Chemical Listed Effective December 4, 2015 as Known to the State of California to Cause Reproductive Toxicity: 2,5-Hexanedione and Addition of a Reproductive Toxicity Endpoint (Developmental) for Methyl-N-Butyl Ketone

2,5-hexanedione (CAS No. 110-13-4) listed effective December 4, 2015 as known to the State to cause reproductive toxicity via the State's Qualified Experts listing mechanim. Additional endpoint listed for methyl-n-butyl ketone (CAS No. 591-78-6).

December 4, 2015: Chemicals Listed Effective December 4, 2015 as Known to the State of California to Cause Cancer: Aloe Vera, Non-Decolorized Whole Leaf Extract and Goldenseal Root Powder

2015 addition of Aloe vera, non-decolorized whole leaf extract and Goldenseal root powder to the list of chemicals known to the State of California to cause cancer.

November 27, 2015: Chemical Listed Effective November 27, 2015 as Known to the State of California to Cause Reproductive Toxicity: Topiramate

Topiramate listed effective November 27, 2015 as known to the state of California to cause reproductive toxicity via the "Formally Required to be Labeled or Identified" listing mechanism

November 27, 2015: Proposed Rulemaking and Announcement of Public Hearing Title 27, California Code of Regulations Proposed Repeal of Article 6 and Adoption of New Article 6 - Clear and Reasonable Warnings

Proposal to repeal Article 6 and at the same time adopt a new Article 6. Modifications to the proposed regulatory language have been made. Public hearing January 2016.

November 27, 2015: Public Hearing Title 27, California Code of Regulations Proposed Repeal of Article 6 and Adoption of New Article 6 - Clear and Reasonable Warnings

Public hearing on January 13, 2016 on new regulations that would further the “right-to-know” purposes of the statute and provide more specific guidance on the content of safe harbor warnings for a variety of exposure situations, and corresponding methods for providing those warnings.