Proposition 65

Proposition 65, officially known as the Safe Drinking Water and Toxic Enforcement Act of 1986, was enacted as a ballot initiative in November 1986. The proposition protects the state's drinking water sources from being contaminated with chemicals known to cause cancer, birth defects or other reproductive harm, and requires businesses to inform Californians about exposures to such chemicals.

Proposition 65 requires the state to maintain and update a list of chemicals known to the state to cause cancer or reproductive toxicity.


Questions about Proposition 65? Check our Frequently asked Questions page or contact the Proposition 65 office: (916) 445-6900 or email

Reports, Notices, Documents

May 1, 1997: Chemicals Listed as Known to the State to Cause Cancer or Reproductive Toxicity
Nine chemicals listed pursuant to the administrative mechanisms for listing based upon either (1) a formal identification by an authoritative body that the chemical is a carcinogen or a reproductive toxicant; or, (2) a formal requirement by a state or federal agency that the chemical be identified or labeled as causing cancer or reproductive toxicity.
Mar 28, 1997: Request for Information, Chemicals Under Consideration for Possible Listing Via Administrative Mechanisms: 20 Chemicals
Request for information on the following chemicals under consideration for listing as known to the State to cause cancer or reproductive toxicity: Trimetrexate Glucuronate, Paclitaxel, Quazepam, Nitrobenzene, Leuprolide Acetate, Ganciclovir Sodium, Goserelin Acetate, Estropipate, Ethionamide, Atenolol, Amiodarone Hydrochloride, C.I. Direct Blue 15, 3,7-Dinitrofluoranthene, 3,9-Dinitrofluoranthene, 1-Amino-2,4-dibromoanthraquinone, C.I. Direct Blue 218, Premarin