Intent to list mitoxantrone hydrochloride as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986 via the “Formally Required to Be Labeled or Identified” listing mechanism.
Proposition 65
Proposition 65, officially known as the Safe Drinking Water and Toxic Enforcement Act of 1986, was enacted as a ballot initiative in November 1986. The proposition protects the state's drinking water sources from being contaminated with chemicals known to cause cancer, birth defects or other reproductive harm, and requires businesses to inform Californians about exposures to such chemicals.
Proposition 65 requires the state to maintain and update a list of chemicals known to the state to cause cancer or reproductive toxicity.
Questions?
Questions about Proposition 65? Check our Frequently asked Questions page or visit our Proposition 65 Warnings website
About Proposition 65
The Safe Drinking Water and Toxic Enforcement Act
The Proposition 65 List
The current Proposition 65 list is dated December 29, 2023
Meetings, Hearings and Workshops
Upcoming and past meetings, hearings and workshops
Notices
All Proposition 65 Notices
Laws and Regulations
Links and downloads related to Proposition 65 statute and regulations
Warnings
Visit this website to learn about warnings for exposures to chemicals on the Proposition 65 List
How chemicals are added to the Proposition 65 list
Learn how chemicals are added to the list
Safe Use Determinations
A Safe Use Determination (SUD) is a written statement issued by OEHHA, which interprets and applies Proposition 65 and its implementing regulations to a specific set of facts in response to a request by a business or a trade group
Interpretive Guidelines for Proposition 65
An Interpretive Guideline interprets Proposition 65 and its implementing regulations, as applied to specific facts
Information Letters
Letters about Proposition 65's application from OEHHA to interested parties.
Warning Regulations
Clear and reasonable warnings
Searchable Proposition 65 Chemical Database
Search the Proposition 65 Chemical Database
Safe harbor levels
Proposition 65 No Significant Risk Levels (NSRLs) and Maximum Allowable Dose Levels (MADLs)
Reports, Notices, Documents
Comment Period on the Request for Relevant Information on the Carcinogenic Hazards of Diaminotoluenes
OEHHA received a petition from Big Lots Stores, Inc. for reconsideration of listing for diaminotoluene (mixed) on October 21, 2014. The CIC will consider the available scientific evidence on the chemical group diaminotoluene and individual isomers and decide whether diaminotoluenes as a group, the mixtures or any individual isomers should be listed under Proposition 65
Comment Period on the request for public participation on potential regulatory actions and the priority level for each potential action
Solicitation of input and information on possible regulatory actions and the priority level for each potential action. OEHHA is planning to schedule a workshop to discuss the next steps in its regulatory reform/update projects.