Proposition 65

Proposition 65, officially known as the Safe Drinking Water and Toxic Enforcement Act of 1986, was enacted as a ballot initiative in November 1986. The proposition protects the state's drinking water sources from being contaminated with chemicals known to cause cancer, birth defects or other reproductive harm, and requires businesses to inform Californians about exposures to such chemicals.

Proposition 65 requires the state to maintain and update a list of chemicals known to the state to cause cancer or reproductive toxicity.


Questions about Proposition 65? Check our Frequently asked Questions page or contact the Proposition 65 office: (916) 445-6900 or email

Reports, Notices, Documents

Dec 2, 2016: Notice of Intent to List Pertuzumab
Notice of Intent to List pertuzumab as known to the state to cause reproductive toxicity (developmental endpoint) under the “Formally Required to Be Labeled or Identified” listing mechanism.
Oct 28, 2016: Response to Petition by the Mateel Environmental Justice Foundation et al.
Response to the petition from Mateel Environmental Justice Foundation, Californians for Alternatives to Toxics, and Ecological Rights Foundation that OEHHA amend California Code of Regulations, title 27, section 27001(c) to list lead as a female reproductive toxicant under Proposition 65.