Streptozotocin

CAS Number

18883-66-4

Synonym

2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-d-glucose; NCI-C03167; STR; Streptozocin; Streptozoticin; STRZ; STZ; Zanosar

Occurrence/Use

Medicine (antibiotic, chemotherapeutic agent). Naturally produced by Streptomyces achromogenes

Cancer Potency Information

Latest Criteria:	Proposition 65 NSRLs/MADLs
Inhalation Unit Risk (μg/cubic meter)-1:	3.1 E-2
Inhalation Slope Factor (mg/kg-day)-1:	1.1 E+2
Oral Slope Factor (mg/kg-day)-1:	1.1 E+2
Comments/References:	OEHHA 1992. Expedited Cancer Potency Values and Proposed Regulatory Levels for Certain Proposition 65 Carcinogens.

Proposition 65

Chemical Status

Cancer:	Currently listed
Reproductive Toxicity:	Currently listed

Cancer

Listed for:	Cancer
Date of Listing:	01/01/1988
Basis for Listing:	State's Qualified Experts

Reproductive Toxicity

Listed for:	Developmental Toxicity Male Reproductive Toxicity Female Reproductive Toxicity
Developmental Toxicity
Date of Listing:	08/20/1999
Basis for Listing:	Formally Required
Male Reproductive Toxicity
Date of Listing:	08/20/1999
Basis for Listing:	Formally Required
Female Reproductive Toxicity
Date of Listing:	08/20/1999
Basis for Listing:	Formally Required

Safe Harbor Levels

Cancer
No Significant Risk Level (NSRL):	0.006 µg/day
Last NSRL/MADL Revision:	1992

Documents, Presentations, and Publications

Cancer:	Expedited Cancer Potency ValuesApr 1, 1992
Reproductive Toxicity:	Listing Notice - 20 Chemicals August 20, 1999 Aug 20, 1999 Package 6a - Chemicals Meeting the Criteria for Listing via the FR Mechanism Mar 19, 1999

Public notices related to this chemical: