Proposition 65

Proposition 65, officially known as the Safe Drinking Water and Toxic Enforcement Act of 1986, was enacted as a ballot initiative in November 1986. The proposition protects the state's drinking water sources from being contaminated with chemicals known to cause cancer, birth defects or other reproductive harm, and requires businesses to inform Californians about exposures to such chemicals.

Proposition 65 requires the state to maintain and update a list of chemicals known to the state to cause cancer or reproductive toxicity.

Questions?

Questions about Proposition 65? Check our Frequently asked Questions page or visit our Proposition 65 Warnings website

Proposition 65 Resources

About Proposition 65

The Safe Drinking Water and Toxic Enforcement Act

The Proposition 65 List

The current Proposition 65 list is dated January 03, 2025

Meetings, Hearings and Workshops

Upcoming and past meetings, hearings and workshops

Notices

All Proposition 65 Notices

Laws and Regulations

Links and downloads related to Proposition 65 statute and regulations

Warnings

Visit this website to learn about warnings for exposures to chemicals on the Proposition 65 List

How chemicals are added to the Proposition 65 list

Learn how chemicals are added to the list

Safe Use Determinations

A Safe Use Determination (SUD) is a written statement issued by OEHHA, interpreting and applying Proposition 65 regulations to specific facts in response to a request by a business or trade group

Interpretive Guidelines for Proposition 65

An Interpretive Guideline interprets Proposition 65 regulations as applied to specific facts

Information Letters

Letters about Proposition 65's application from OEHHA to interested parties

Warning Regulations

Clear and reasonable warnings

Searchable Proposition 65 Chemical Database

Search the Proposition 65 Chemical Database

Safe harbor levels

Proposition 65 No Significant Risk Levels (NSRLs) and Maximum Allowable Dose Levels (MADLs)

Reports, Notices, Documents

El Departamento de Reglamentación de Pesticidas (DPR por sus siglas en inglés) de California ha propuesto nuevas reglamentaciones elaboradas de manera conjunta y mutua con la Oficina de Evaluación de Riesgos para la Salud Ambiental (OEHHA, por sus siglas en inglés) para proteger espectadores ocupacionales en los alrededores de campos tratados para reducir su riesgo de exposición al 1,3-D.

The Office of Environmental Health Hazard Assessment (OEHHA) has amended Title 27, California Code of Regulations 25607.2(b), to provide an additional safe harbor warning option for businesses that cause significant exposures to acrylamide in food products. 

The Office of Environmental Health Hazard Assessment proposes to adopt a Proposition 65 No Significant Risk Level for titanium dioxide (airborne, unbound particles of respirable size) by amending Title 27, California Code of Regulations, section 25705(c)(2).

OEHHA may send letters to interested parties that assist in understanding Proposition 65 statutes and regulations, and their application.

The Office of Environmental Health Hazard Assessment convened a meeting of the CIC on February 27th, 2024. The meeting opened with a session on enzyme polymorphisms and susceptibility to carcinogenicity, including presentations from invited speakers and discussions with the Committee. The presentations and discussion will help inform future cancer hazard identification work at OEHHA. The Committee also discussed OEHHA’s proposal to streamline several sections of cancer hazard identification documents.