Chemicals Proposed for Listing by the Labor Code Mechanism (Reproductive and Developmental Toxicants)
The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is requesting comments as to whether the chemicals identified in the table below meet the requirements for listing under the Safe Drinking Water and Toxic Enforcement Act of 1986. The Act, commonly known as Proposition 65, is codified in Health and Safety Code section 25249.5 et seq. This action is being taken pursuant to Health and Safety Code section 25249.8(a).
Chemicals Proposed for Listing Via the Labor Code
Chemical | CAS No. | Endpoint | Reference |
---|---|---|---|
Tert-Amyl methyl ether | 994-05-8 | Developmental | ACGIH (2009) |
n-Butyl glycidyl ether | 2426-08-6 | Male reproduction | ACGIH (2009) |
Carbaryl | 63-25-2 |
Male reproduction |
ACGIH (2009) |
Chloroform | 67-66-3 | Developmental | ACGIH (2009) |
2-Chloropropionic acid | 598-78-7 | Male reproduction | ACGIH (2009) |
Dichloroacetic acid | 79-43-6 | Male reproduction | ACGIH (2009) |
Diglycidyl ether | 2238-07-5 | Male reproduction | ACGIH (2009) |
N,N-dimethylacetamide | 127-19-5 | Developmental | ACGIH (2009) |
Ethylene oxide |
75-21-8 |
Male reproduction Developmental1 |
29 CFR part 1910, Subpart Z |
Ethyl-tert-butyl ether | 637-92-3 | Male reproduction | ACGIH (2009) |
2-Ethylhexanoic acid | 149-57-5 | Developmental | ACGIH (2009) |
Methyl chloride | 74-87-3 | Male reproduction2 | ACGIH (2009) |
Methyl n-butyl ketone | 591-78-6 | Male reproduction | ACGIH (2009) |
p,p’-Oxybis(benzenesulfonyl hydrazide) | 80-51-3 | Developmental | ACGIH (2009) |
Phenyl glycidyl ether | 122-60-1 | Male reproduction | ACGIH (2009) |
Phenylphosphine | 638-21-1 | Developmental | ACGIH (2009) |
Toluene | 108-88-3 | Female reproduction2 | ACGIH (2009) |
1,3,5-Triglycidyl-s-triazinetrione | 2541-62-9 | Male reproduction | ACGIH (2009) |
4-Vinyl-cyclohexene | 100-40-3 |
Male reproduction |
ACGIH (2009) |
1Already on the Proposition 65 list on the basis of female reproductive toxicity
2Already on the Proposition 65 list on the basis of developmental toxicity
Background on listing by the Labor Code mechanism: Health and Safety Code section 25249.8(a) incorporated certain provisions of the California Labor Code into Proposition 65. The law requires that certain substances identified as causing reproductive toxicity in 29 CFR part 1910, Subpart Z, Toxic and Hazardous Substances, Occupational Safety and Health Administration or in the Threshold Limit Values for Chemical Agents in the Work Environment, American Conference of Governmental Industrial Hygienists [ACGIH] (latest edition) be listed as known to cause reproductive toxicity under Proposition 65. As the lead agency for the implementation of Proposition 65, the OEHHA evaluates whether listing under Proposition 65 is required.
OEHHA’s determination: In the case of all of the above-identified chemicals except ethylene oxide, the ACGIH Threshold Limit Value was established based solely or in part on a relevant reproductive or developmental effect. In the case of ethylene oxide, Title 29 of the Code of Federal Regulations, section 1910, subpart Z, identifies the chemical as causing developmental and male reproductive toxicity.
Request for comment: OEHHA is requesting comments as to whether the chemicals identified above meet the requirements for listing as causing reproductive toxicity, as specified in Health and Safety Code section 25249.8(a). Because these are ministerial listings, comments should be limited to the question whether the ACGIH has established a TLV for the chemical or substance that is based in whole or in part on a reproductive or developmental effect, or whether OSHA has identified the chemical as causing reproductive or developmental effects in Title 29, CFR section 1910, subpart Z. Under this listing mechanism, OEHHA cannot consider scientific arguments concerning the weight or quality of the evidence and will not respond to such comments if they are submitted.
OEHHA must receive comments by 5:00 p.m. on Monday, July 13, 2009. A public workshop will be held only upon request. Such request must be made in writing to the address below within 10 days from the publication of this notice. We encourage you to submit comments in electronic form, rather than in paper form. Comments transmitted by e-mail should be addressed to coshita@oehha.ca.gov. Comments submitted in paper form may be mailed, faxed, or delivered in person to the address below. A public workshop will be held only upon request. Such request must be made in writing to the address below within 10 days from the publication of this notice:
Mailing Address:
Ms. Cynthia Oshita
Office of Environmental Health Hazard Assessment
P.O. Box 4010, MS-19B
Sacramento, California 95812-4010
Fax: (916) 323-8803
Street Address: 1001 I Street
Sacramento, California 95814
If you have any questions, please contact the Proposition 65 Office at (916) 445-6900.
Comment Period
Comment Period - Chemicals Proposed for Listing by the Labor Code MechanismLink to Public Comments
Downloads
Chemical Reference
- Ethylene Oxide
- Toluene
- Chloroform
- Phenyl Glycidyl Ether
- 4-Vinylcyclohexene
- 2-Chloropropionic Acid
- Carbaryl
- Dichloroacetic Acid
- Methyl-n-Butyl Ketone
- Methyl Chloride
- N,N-Dimethylacetamide
- Phenylphosphine
- 1,3,5-triglycidyl-s-triazinetrione
- Diglycidyl ether
- n-Butyl glycidyl ether
- 2-Ethylhexanoic acid
- p,p’‑oxybis(benzenesulfonyl hydrazide)
- Tert-Amyl methyl ether
- Ethyl-tert-butyl ether