%1

The Office of Environmental Health Hazard Assessment (OEHHA) is releasing a draft document for public review, summarizing the toxicity and derivation of proposed Reference Exposure Levels (RELs) for Chromium (Trivalent) and Inorganic Water-Soluble Trivalent Chromium Compounds (Cr(III)).

Hexamethylene Diisocyanates (Polydiisocyanates)

Acute REL (μg/m3)
4.5
Species
Rodents
Acute REL Toxicologic Endpoint
Respiratory system
8-Hour Inhalation REL (μg/m3)
0.8
Last 8-Hour REL Revision
09/06/2019
Chronic Inhalation REL (μg/m3)
0.4
Chronic Toxicologic Endpoint
Pulmonary inflamation and fibrosis in rodents
Chronic Target Organs
Respiratory system
Last Chronic REL Revision
09/06/2019
Last Acute REL Revision
09/06/2019

Hexamethylene Diisocyanate (Monomer)

Acute REL (μg/m3)
0.3
Species
Rodents
Acute REL Toxicologic Endpoint
Nasal epithelium lesions
Acute REL Target Organs
Respiratory system
8-Hour Inhalation REL (μg/m3)
0.06
Last 8-Hour REL Revision
09/06/2019
Chronic Inhalation REL (μg/m3)
0.03
Chronic Toxicologic Endpoint
HDI-induced asthma; accelerated decline in lung function
Chronic Target Organs
Respiratory system
Human Data
Yes
Last Chronic REL Revision
09/06/2019
Last Acute REL Revision
09/06/2019

The Office of Environmental Health Hazard Assessment is adopting new cancer inhalation unit risk and slope factors for Cobalt and Cobalt Compounds for use in the Air Toxics Hot Spots Program.  Inhalation unit risks are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen. 

The Office of Environmental Health Hazard Assessment (OEHHA) is adopting new Reference Exposure Levels (RELs) for Toluene for use in the Air Toxics Hot Spots Program. RELs are airborne concentrations of a chemical that are not anticipated to result in adverse noncancer health effects for specified exposure durations in the general population, including sensitive subpopulations.

OEHHA is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360(b)(2)).  In implementing this requirement, OEHHA develops new IURs and revises existing IURs for many air pollutants.

The Office of Environmental Health Hazard Assessment (OEHHA) is releasing a draft document summarizing the carcinogenicity and derivation of a cancer inhalation unit risk factor (IUR) for p‑Chloro-α,α,α-trifluorotoluene (p-chlorobenzotrifluoride, PCBTF).  IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen.

OEHHA has received a request from the American Coatings Association to extend the public comment period. This notice extends the comment period to December 17, 2019.

Comment Submissions - Draft Hot Spots Cancer Inhalation Unit Risk Factors for p Chloro-α,α,α-trifluorotoluene (p-chlorobenzotrifluoride, PCBTF)

Docket Status
Closed