Toluene
CAS Number
108-88-3Synonym
Antisal 1A; Anisen; Caswell No. 859; CP 25; Methacide; Methylbenzene; Methylbenzol; NCI-C07272; Phenylmethane; Toluol
Occurrence/Use
Solvent, jet fuel component and gasoline additive, cement for polystyrene kits; production of polymers; chemical intermediate (benzene dealkylation); component of car exhaust and tobacco smoke
| Last CHHSL revision: |
1/2005
|
|---|---|
| CHHSL Comments: |
For chemical-specific screening levels for use in assessing contaminated sites, please see HHRA Note 3 (DTSC HERO). https://www.dtsc.ca.gov/assessingrisk/humanrisk2.cfm |
| Latest Criteria: |
Chronic Reference Exposure Levels
|
|---|
Air
| Acute REL (μg/m3): |
5000
|
|---|---|
| Species: |
Human
|
| Acute REL Toxicologic Endpoint: |
Headache, dizziness, slight eye and nose irritation
|
| Acute REL Target Organs: |
Nervous system; eyes; respiratory system
|
| Last Acute REL Revision: |
2020
|
| Acute Reference Exposure Levels Comments: |
| 8-Hour Inhalation REL (μg/m3): |
830
|
|---|---|
| Last 8-Hour REL Revision: |
August, 2020
|
| 8-Hour Reference Exposure Levels Comments: |
| Chronic Inhalation REL (μg/m3): |
420
|
|---|---|
| Chronic Target Organs: |
Acquired color vision impairment (dyschromatopsia)
|
| Human Data: |
Yes
|
| Last Chronic REL Revision: |
2020
|
| Chronic Reference Exposure Levels Comments: |
Proposition 65
| Reproductive Toxicity: |
Currently listed
|
|---|
| Listed as causing: |
Developmental Toxicity
|
|---|---|
| Developmental Toxicity | |
| Date of Listing: |
01/01/1991
|
| Basis for Listing: |
State's Qualified Experts
|
| Female Reproductive Toxicity | |
| Date of Listing: |
08/07/2009
|
| Date of Delisting: |
03/07/2014
|
| Basis for Listing: |
Labor Code
|
| Reproductive Toxicity | |
| Maximum Allowable Dose Level (MADL) - Inhalation: |
13000 µg/day
|
|---|---|
| Maximum Allowable Dose Level (MADL) - Oral: |
7000 µg/day
|
Public notices related to this chemical:
- Change in the Identification of Reproductive Toxicity Endpoints in the Listing of Toluene as Known to Cause Reproductive Toxicity
- Chemicals Listed Effective August 7, 2009 as Known to the State of California to Cause Cancer or Reproductive Toxicity
- Chemicals Proposed for Listing by the Labor Code Mechanism (Reproductive and Developmental Toxicants)
- Final Statement of Reasons - Reproductive Toxicants: Toluene
Water
| Health Risk Category: |
Hepatotoxicity (liver), endocrine toxicity (thymus)
|
|---|---|
| Public Health Goal (mg/L): |
0.15
|
| Public Health Goal - Download: | |
| Cancer Risk at PHG: |
n/a
|
| MCL value (mg/L): |
0.15
|
| Cancer Risk at MCL: |
n/a
|
| Last PHG Revision : |
1999
|
| California PHG Comments: |
Comments
Female reproductive toxicity endpoint removed from listing for toluene effective March 7, 2014.