Proposition 65

Proposition 65, officially known as the Safe Drinking Water and Toxic Enforcement Act of 1986, was enacted as a ballot initiative in November 1986. The law protects the state's drinking water sources from being contaminated with chemicals known to cause cancer, birth defects or other reproductive harm, and requires businesses to inform Californians about exposures to such chemicals.

Proposition 65 requires the state to maintain and update the list of chemicals subject to the law’s requirements.

Questions about Proposition 65?  Visit our Proposition 65 Warnings website.

Proposition 65 Resources

About Proposition 65

The Safe Drinking Water and Toxic Enforcement Act

The Proposition 65 List

The current Proposition 65 list is dated December 08, 2025

Meetings, Hearings and Workshops

Upcoming and past meetings, hearings and workshops

Notices

All Proposition 65 Notices

Laws and Regulations

Links and downloads related to Proposition 65 statute and regulations

Warnings

Visit this website to learn about warnings for exposures to chemicals on the Proposition 65 List

How chemicals are added to the Proposition 65 list

Learn how chemicals are added to the list

Safe Use Determinations

A Safe Use Determination (SUD) is a written statement issued by OEHHA, interpreting and applying Proposition 65 regulations to specific facts in response to a request by a business or trade group

Interpretive Guidelines for Proposition 65

An Interpretive Guideline interprets Proposition 65 regulations as applied to specific facts

Information Letters

Letters about Proposition 65's application from OEHHA to interested parties

Warning Regulations

Clear and reasonable warnings

Searchable Proposition 65 Chemical Database

Search the Proposition 65 Chemical Database

Safe harbor levels

Proposition 65 No Significant Risk Levels (NSRLs) and Maximum Allowable Dose Levels (MADLs)

Reports, Notices, Documents

Hazard Identification Materials for 1,3-Dichloro-2-propanol (1,3 DCP) and 3-Monochloropropane-1,2-diol (3-MCPD) for public comment and review.  CIC meeting on September 21st and 22nd, 2010 in Sacramento CA.

Information reguarding OEHHA's work to initiate a discussion of possible approaches to providing warnings for exposures to listed chemicals in foods and exposures to human and plant nutrients in human food.

Effective June 11, 2010, OEHHA will remove male reproductive toxicity as a basis for the listing of chlorsulfuron.  Chlorsulfuron will remain on the Proposition 65 list based on U.S. EPA’s findings of developmental and female reproductive toxicity.

OEHHA announces the withdrawal of its regulatory proposal for possible amendments to Sections 25801, 25803 and 25805 of the Proposition 65 implementing regulations. These sections establish the procedures for calculating “safe harbor” levels for chemicals listed under Proposition 65.

Request for comments and feedback on the re-drafted regulatory language for the Retail Food Warning Program and draft statement of reasons for the regulation.