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July 12 And 13, 2011 Meeting of the Developmental and Reproductive Toxicant Identification Committee (DART IC)

The Developmental and Reproductive Toxicant Identification Committee of OEHHA’s1 Science Advisory Board identifies chemicals for addition to the list of chemicals known to the State to cause reproductive toxicity (Health and Safety Code section 25249.8).  The Committee serves as the “State’s Qualified Experts” for determining whether a chemical has been clearly shown, through scientifically valid testing according to generally accepted principles, to cause reproductive toxicity.

A public meeting of this committee will be held on Tuesday and Wednesday, July 12 and 13, 2011.  The meeting will be available via webcast.  On the day of the meeting, the link to the webcast will be posted on the OEHHA web site.  If you have special accommodation or language needs, please contact the Proposition 65 Office at (916) 445-6900.  TTY/TDD/Speech-to-Speech users may dial 7‑1‑1 for the California Relay Service.

AGENDA

I. WELCOME AND OPENING REMARKS
George Alexeeff, Ph.D., Acting Director, Office of Environmental Health Hazard Assessment (OEHHA)

II.CONSIDERATION OF A CHEMICAL AS KNOWN TO THE STATE TO CAUSE REPRODUCTIVE TOXICITY

A. Sulfur Dioxide*

* A staff presentation followed by public comment and committee discussion will be made for each toxicity endpoint (male reproductive, developmental and female reproductive). The committee decisions will occur after all three endpoints have been discussed.

  • Staff presentations

    “Epidemiologic studies used for setting air pollution standards”

    “Evidence of the developmental and reproductive toxicity of sulfur dioxide”
  • Public comments
  • Committee discussion and decision

III. PROPOSITION 65 LISTING MECHANISMS (INFORMATIONAL ITEM)

  • Staff presentations
  • Public comments
  • Committee discussion

IV. CONSIDERATION OF THE DESIGNATION OF THE NATIONAL TOXICOLOGY PROGRAM (NTP) AS AN AUTHORITATIVE BODY

  • Staff presentation
  • Presentation by National Toxicology Program Staff
    Editorial in Environmental Health Perspectives - The Office of Health Assessment and Translation: A Problem-Solving Resource for the National Toxicology Program
  • Committee consideration of identification of NTP as an authoritative body and consideration of the petition filed on August 5, 2010 on behalf of the Polycarbonate/BPA Global Group of the American Chemistry Council to reconsider the designation of NTP-CERHR (Center for the Evaluation of Risks to Human Reproduction) as an authoritative body for purposes of identifying reproductive toxins
  • June 28, 2011 Letter from F. Jay Murray, Ph.D.
  • July 7, 2011 Letter from Stan Landfair
  • July 7, 2011 Letter #2 from Stan Landfair
  • July 8, 2011 Letter from Gene Livingston et al.
  • July 11, 2011 Letter from Patricia Magee Vaughan
  • Public comments
  • Committee discussion and decision

V. PRIORITIZATION OF CHEMICALS FOR FUTURE DEVELOPMENTAL AND REPRODUCTIVE TOXICANT IDENTIFICATION COMMITTEE REVIEW

  • Staff presentations on five chemicals (benzo(a)pyrene, deltamethrin, methyl parathion, uranium, and xylene)
  • Public comments
  • Committee discussion and advice and consultation regarding possible development of hazard identification materials

VI. UPDATE OF THE LIST OF “CHEMICALS WHICH HAVE NOT BEEN ADEQUATELY TESTED AS REQUIRED”

  • Carol Monahan-Cummings, Chief Counsel, OEHHA

VII. STAFF UPDATES

  • Chemical listings and safe harbor level development
    (the Proposition 65 Office, Proposition 65 Implementation, OEHHA)
  • Proposition 65 litigation
    (Carol Monahan-Cummings, Chief Counsel, OEHHA)

VIII. SUMMARY OF COMMITTEE ACTIONS
George Alexeeff, Ph.D., Acting Director, OEHHA

Meeting Synopsis of the Developmental and Reproductive Toxicant Identification Committee Meeting Held on July 12 and 13, 2011

The California Environmental Protection Agency’s (Cal/EPA), Office of Environmental Health Hazard Assessment (OEHHA) convened a meeting of the Proposition 65 Developmental and Reproductive Toxicant Identification Committee (DARTIC) on July 12 and 13, 2011. The meeting was held at the Cal/EPA Headquarters Building in Sacramento, California. 

The Committee:

  • Considered the listing of sulfur dioxide as known to the state cause reproductive toxicity.
  • Received an informational presentation on the Proposition 65 listing mechanisms.
  • Received an informational presentation on how the National Toxicology Program evaluates reproductive and developmental hazards and about its new Office of Health Assessment and Translation (OHAT).
  • Discussed the petition filed by the Polycarbonate/BPA Global Group of the American Chemistry Council to reconsider the designation of the “National Toxicology Program, solely as to final reports of the Center for the Evaluation of Risks to Human Reproduction” (NTP-CERHR) as an authoritative body.
  • Discussed whether to change the designation of the NTP as an authoritative body in light of the establishment of OHAT.
  • Advised OEHHA on the prioritization of candidate chemicals for future DARTIC review and listing decisions.
  • Received updates on recent Proposition 65 activities.

SUMMARY OF THE LISTING DECISION FOR SULFUR DIOXIDE

Following a staff presentation, comments from the public and committee discussion, the DARTIC determined that sulfur dioxide has been clearly shown to cause developmental toxicity based on findings of low birth weight in scientific studies.  The chemical was added to the Proposition 65 chemical list as known to cause reproductive toxicity (developmental toxicity endpoint) effective July 29, 2011.  The DARTIC did not find that sulfur dioxide has been clearly shown to cause female or male reproductive toxicity.

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