Developmental and Reproductive Toxicant Identification Committee (DARTIC) Members

The Developmental and Reproductive Toxicant Identification Committee (DARTIC) is a group of expert scientists appointed by the Governor to identify chemicals that have been clearly shown through scientifically valid testing according to generally accepted principles to cause reproductive toxicity. (Cal. Health & Safety Code § 25249.8).

A Committee of Experts

The Developmental and Reproductive Toxicant Identification Committee (DARTIC) includes experts from among the following areas of specialization: epidemiology, developmental toxicology, reproductive toxicology, teratology, medicine, public health, statistics, biology, toxicology, and related fields.

An Expert Determination

The committee meets at least once each calendar year.

The addition of a chemical to the Proposition 65 list by the committee requires three steps:

During the months prior to each meeting, scientists from the Office of Environmental Health Hazard Assessment prepare hazard identification materials, commonly in the form of a hazard identification document, presenting the scientific evidence on a chemical’s reproductive toxicity. The public has an opportunity to submit relevant information to OEHHA that may be included in the materials. The hazard identification materials are released to the public for a 45-day comment period. Committee members then review the materials as well as the public comments received.
At the meetings, committee members have a chance to hear public testimony on the chemical and then review, discuss, and vote on the evidence they have seen and heard.
Members will vote on whether a chemical “has been clearly shown through scientifically valid testing according to generally accepted principles to cause reproductive toxicity.” (Cal. Health & Safety Code § 25249.8). Members usually will further specify whether the chemical has been clearly shown to cause male reproductive toxicity, female reproductive toxicity and/or developmental toxicity. Chemicals [KV1] are added to the list of a majority of the appointed members vote “yes”.

The committee has developed guidance for its use in identifying chemicals for listing under Proposition 65 as reproductive toxicants.

Members of the committee also have the authority to suggest and prioritize chemicals for future review. They also identify the “authoritative bodies” (such as the U.S. Environmental Protection Agency) whose formal identifications of reproductive toxicants can qualify chemicals for listing by the authoritative bodies listing mechanism. (Cal. Health & Safety Code § 25249.8).

The Developmental and Reproductive Toxicant Identification Committee Members are:

Patrick Allard is an associate professor and vice chair of undergraduate education at the University of California, Los Angeles (UCLA) Institute for Society and Genetics within the College of Life Sciences. He has been at UCLA since 2012. He was a post-doctoral fellow at Harvard Medical School from 2005 to 2012. Allard earned a Doctor of Philosophy degree in biology from McGill University and a Master of Science in the biology of aging from the Paris Descartes University. Dr. Allard’s work includes publications on reproductive and transgenerational effects of environmental chemicals, and his research focuses on the effects of environmental stressors over the life course and across generations.
Diana Auyeung-Kim has been Executive Director / Head of Research and Early Development (gRED) Nonclinical Operations (gNO) at Genentech since 2020 and with the company since 2017. Previously, at Allergan plc, she was director in toxicology and nonclinical and translational sciences study support from 2015 to 2017 and principal scientist/senior manager in toxicology from 2010 to 2014. She held several positions at Charles River Laboratories Inc. from 2002 to 2010, including program associate for developmental and reproductive toxicology, associate director of research, senior research scientist, and research scientist. Auyeung-Kim was a human health risk assessor and assistant project manager at TetraTech EM Inc. from 1993 to 2000 and a certified pharmacy technician at Sutter and Mercy General Hospitals from 1989 to 1992. She is a member of The Teratology Society, the Society of Toxicology, American College of Toxicology and is a Diplomate of the American Board of Toxicology. She earned a Doctor of Philosophy degree in pharmacology and toxicology from the Virginia Commonwealth University and a Master of Business Administration degree from the University of Nevada, Reno.
Laurence Baskin has been a professor of urology and pediatrics at the University of California, San Francisco (UCSF) since 2004 and a surgeon scientist at UCSF since 1993. In 1997, he was appointed chief of pediatric urology. He is primary author on over 200 peer-reviewed articles, editor of the Handbook of Pediatric Urology, Hinman’s atlas of Pediatric Urologic Surgery and Assistant editor of the pediatric section, Journal Urology. He is Principal Investigator on basic urologic research, clinical and mentoring grants funded by the National Institutes of Health (NIH) and National Science Foundation. He is presently head of the NIH study section on urologic disease. He is president of the Society for Pediatric Urology and was previously president of the Society for Fetal Urology, the Asia-Pacific Association of Pediatric Urology, the Society of Genitourinary Reconstructive Surgeons and the American Association of Pediatric Urology. He is a member of the American Urological Association and the Society of Pediatric Urologic Surgeons and a fellow at the American College of Surgeons and American Academy of Pediatrics. He earned a doctorate degree in medicine at the University of California, Los Angeles.
Carrie Breton has been an associate professor at the University of Southern California (USC) since 2017 and director of the Maternal and Developmental Risks from Environmental and Social Stressors Center for Environmental Health Disparities since 2015. At USC she has held several positions, including assistant professor from 2009 to 2017, post-doctoral fellow from 2007 to 2009 and project assistant from 1999 to 2000. Breton earned a Doctor of Science degree in epidemiology from the Harvard School of Public Health and a Master of Public Health degree in epidemiology from the University of California, Los Angeles School of Public Health.
Martine Culty has been associate professor of Pharmacology and Pharmaceutical Sciences in the School of Pharmacy at the University of Southern California since 2016. She was an Associate Professor for the McGill University Faculty of Medicine from 2007 to 2016. She has held several positions at Georgetown University including associate professor from 2005 to 2007 and assistant professor from 1990 to 2005. She is a member of the Society of Toxicology, American Society of Andrology, Society for the Study of Reproduction, and the Endocrine Society. She earned a Doctor of Philosophy degree in Molecular Chemistry and a Master of Science degree in Molecular and Cellular Biology from Université Grenoble Alpes.
Sandie Ha is an associate professor at the University of California, Merced, where she has worked since 2017. She was an Intramural Research Training Award Postdoctoral Fellow at the National Institute of Child Health and Human Development from 2015 to 2017. She is a member of the American Public Health Association, Society for Epidemiologic Research, Society for Pediatric and Perinatal Epidemiologic Research, and the National Faculty of the National Board of Osteopathic Medical Examiners. She earned a Doctor of Philosophy degree in Epidemiology from the University of Florida and a Master of Public Health degree from the University of Florida.
Kim Harley has been an Adjunct Professor for the School of Public Health at the University of California, Berkeley (UC Berkeley) since 2009. She is Faculty Director of the Wallace Center for Maternal, Child and Adolescent Health, and has been Associate Director for Health Effects at the Center for Environmental Research and Children’s Health, School of Public Health at UC Berkeley since 2004. She is a member of the International Society for Children's Health and the Environment, International Society for Environmental Epidemiology, and the International Society of Exposure Science. She earned a Doctor of Philosophy degree in Epidemiology and a Master of Public Health degree in Maternal and Child Health from UC Berkeley.
Irva Hertz-Picciotto has been a professor at the University of California, Davis since 2002. She was a professor at the University of North Carolina, Chapel Hill from 1990 to 2003 and visiting scholar at the National Institute of Environmental Health Sciences from 1989 to 1990. Hertz-Picciotto is a member of the Society for Epidemiologic Research, International Society for Environmental Epidemiology, and the International Society for Autism Research. She has served as Chair for four committees of the National Academy of Sciences, Engineering, and Medicine since 2000. She earned a Doctor of Philosophy degree in epidemiology, Master of Arts degree in biostatistics and Master of Public Health degree in epidemiology from the University of California, Berkeley.
Ulrike Luderer has served as Chair of the Developmental and Reproductive Toxicant Identification Committee since 2019. She has been a professor in the Department of Medicine, Division of Occupational and Environmental Medicine at the University of California, Irvine since 2013 and was associate professor from 2006 to 2013 and assistant professor from 1999 to 2006. She was a senior postdoctoral fellow at the University of Washington Department of Environmental and Occupational Health Sciences from 1998 to 1999 and completed her fellowship in occupational and environmental medicine there in 1998. She is a member of the Society for the Study of Reproduction, the Endocrine Society, the Society of Toxicology and the American College of Occupational and Environmental Medicine. She is a member of the California Environmental Contaminant Biomonitoring Program scientific guidance panel and served on the U.S. Environmental Protection Agency Science Advisory Board, Environmental Health Committee, among other service on national and international advisory panels. She earned a Master of Public Health degree from the University of Washington and doctorate degrees in neurobiology and physiology and in medicine from Northwestern University. She is board-certified in occupational medicine and internal medicine.
Isaac Pessah has been a professor at the University of California, Davis since 1996 and has served as Chair of the Department of Molecular Biosciences since 2006. He was associate professor at the UC Davis from 1994 to 1998, assistant professor from 1987 to 1994 and a research specialist at the University of California, Berkeley from 1984 to 1987. He is a member of the American Chemical Society, the Society of Toxicology, the Biophysical Society and the American Society for Pharmacology and Experimental Therapeutics. He earned a Master of Science degree and a doctorate degree in toxicology from the University of Maryland.
Charles Plopper has been professor emeritus at the University of California, Davis School of Veterinary Medicine's Department of Anatomy, Physiology and Cell Biology since 2005, where he has served in several positions since 1979, including chairperson, acting chairperson, professor, associate professor, and assistant professor. He was a senior staff fellow at the National Institute of Environmental Health Sciences Laboratory of Pulmonary Function and Toxicology from 1978 to 1979, associate professor at the University of Kuwait Department of Human Morphology and Experimental Pathology from 1977 to 1978, assistant professor at the University of Hawaii John A. Burns School of Medicine's Department of Anatomy and Reproductive Biology from 1975 to 1977 and a visiting research morphologist at the University of California, Davis California National Primate Research Center from 1974 to 1975. He was chief of the Electron Microscopy Division at the Letterman Army Institute of Research, Presidio of San Francisco from 1974 to 1975 and chief of the U.S. Army Medical Research and Nutrition Laboratory's Electron Microscopy Branch, Pathology Division from 1972 to 1973. He earned a Doctor of Philosophy degree in anatomy from the University of California, Davis.