Request for Relevant Information on the Reproductive Toxicity of p,p’-bisphenol Chemicals

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of Proposition 65^[1].  The Developmental and Reproductive Toxicant Identification Committee (DARTIC) of OEHHA’s Science Advisory Board serves as the state’s qualified experts and renders an opinion about whether a chemical has been clearly shown to cause reproductive toxicity^[2]. The chemicals identified by the DARTIC are added to the Proposition 65 list.

OEHHA has selected p,pʹ-bisphenol chemicals for the DARTIC’s review for possible listing under Proposition 65 as causing reproductive toxicity. p,pʹ-Bisphenol chemicals include p,pʹ-bisphenols, and ethers and esters of p,pʹ-bisphenols. OEHHA is initiating the development of hazard identification materials on these chemicals.

Relevant information on p,pʹ-bisphenol chemicals includes but is not limited to:

• Animal studies examining reproductive toxicity (evidence of developmental and male and female reproductive toxicity)
• Epidemiological studies in humans
• Studies related to mechanisms of reproductive or developmental toxicity
• Other pertinent studies on:
  • Pharmacokinetics
  • Effects on biochemical and physiological processes, including findings in humans

Hazard identification materials for these chemicals will be presented at a future meeting of the DARTIC for Committee consideration of possible listings of the chemicals under Proposition 65.

By this notice, OEHHA is giving the public an opportunity to provide information relevant to the assessment of the evidence of reproductive toxicity for p,pʹ-bisphenol chemicals.  Interested parties or members of the public wishing to provide such information should submit it in accordance with the instructions given below. 

The publication of this notice marks the start of a 45-day data call-in period, ending on Monday, December 1, 2025. The information received during this period will be reviewed and considered by OEHHA as it prepares the hazard identification materials on the reproductive toxicity of p,pʹ-bisphenol chemicals.

Hazard identification materials are made available to the public for comment prior to the DARTIC’s consideration of the chemical(s) for possible listing.  The availability of the hazard identification materials will be announced in the California Regulatory Notice Register and on OEHHA’s website.  Public comments received on these materials will be sent to the DARTIC for its consideration prior to the meeting at which the chemical(s) are considered for listing.  The time, date, location, and agenda of the DARTIC meeting where a chemical will be considered for listing will be published in the California Regulatory Notice Register and posted on OEHHA’s website.

We encourage you to submit relevant information responsive to this request in electronic form, rather than in paper form.  Comments may be submitted electronically through our website at https://oehha.ca.gov/comments. Comments submitted in paper form can be mailed, faxed, or delivered in person to the addresses below:

Mailed submission via United States Postal Service:

Attention: Tina Cox
Office of Environmental Health Hazard Assessment
P. O. Box 4010
Sacramento, California 95812-4010

In-person delivery submission:

Attention: Tina Cox
Office of Environmental Health Hazard Assessment 
1001 I Street
Sacramento, California 95814

OEHHA encourages all commenters to submit their comments in a format compliant with Section 508 of the federal Rehabilitation Act, Web Content Accessibility Guidelines 2.1 (https://www.w3.org/WAI/standards-guidelines/wcag) and California Government Code sections 7405 and 11135, so that they can be read using screen reader technology.

OEHHA is subject to the California Public Records Act and other laws that require the release of certain information upon request. If you provide a submission, your comment may be available to third parties.

If you have any questions, please contact Tina Cox at tina.cox@oehha.ca.gov or at (916) 327-7338.