Overview of the 2022 Meeting of the Developmental and Reproductive Toxicant Identification Committee (DARTIC)

Feb 3, 2023

Video of 2022 DARTIC Meeting – Part 1
Video of 2022 DARTIC Meeting – Part 2

A meeting of the Proposition 65 ^[1] Developmental and Reproductive Toxicant Identification Committee (DARTIC)^[2] was held on October 18, 2022. The main agenda item was on the use of zebrafish data in developmental and reproductive toxicant health hazard assessment. Zebrafish are increasingly used as a model organism in toxicity testing, including for developmental and reproductive toxicity. OEHHA has included zebrafish study data and other types of new toxicological data in our hazard identification documents. The DARTIC meeting explored the scientific underpinnings and further use of Zebrafish evidence in identifying chemicals posing reproductive hazards, to inform future use of these data.

At the meeting, the DARTIC also voted in favor (9-0) of the consent item to remove bromadiolone from the list of chemicals for which testing is required but has been inadequate (California Code of Regulations (CCR) Title 27 Section 27000). As described in the OEHHA staff report, data requirements for bromadiolone have been fulfilled. This list of chemicals is distinct from the Proposition 65 list.

Finally, OEHHA staff presented updates on chemical listing via the administrative listing mechanisms, safe harbor levels, and other regulations and litigation from the past year.

No Proposition 65 listing decisions were considered or made at this meeting.

A recording of the full meeting and transcript is available online.

Meeting Agenda

Welcome and Opening Remarks
Session on use of zebrafish data in DART health hazard assessment*
- Introduction to the Use of Zebrafish Data in DART Health Hazard Assessment Presentation: Dr. Marlissa Campbell, OEHHA
- Part I. Zebrafish biology and suitability for toxicity screening
  - Presentation: Dr. Bruce Draper, University of California Davis
  - Presentation: Dr. Stephanie Padilla, US Environmental Protection Agency
- Part II. Beyond Screening: zebrafish as a model for developmental mechanisms at the cellular and molecular level
  - Presentation: Dr. Jennifer Panlilio, Woods Hole Center for Oceans and Human Health
  - Presentation: Dr. Dan Wagner, University of California San Francisco
- Part III. Use of zebrafish data in DART health hazard assessment
- Public comment
- Committee discussion
Consent Item - Update of the California Code of Regulations Title 27 Section 27000 List of Chemicals Which Have Not Been Adequately Tested as Required
Staff Updates
- Chemical listings via the administrative listing mechanisms
- Safe harbor levels
- Other regulations and litigation
Summary of Committee Actions

*Invited speaker presentations available upon request.