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Nickel Subsulfide

CAS Number

12035-72-2

Synonym

Heazlewoodite; Nickel sulfide; Nickel tritadisulphide; Trinickel disulphide

Occurrence/Use

Component of nickel refinery dust

Nickel Subsulfide

Soil Screening

Last CHHSL revision: 
1/2005
CHHSL Comments: 

For chemical-specific screening levels for use in assessing contaminated sites, please see HHRA Note 3 (DTSC HERO). https://www.dtsc.ca.gov/assessingrisk/humanrisk2.cfm

Cancer Potency Information

Inhalation Unit Risk (μg/cubic meter)-1: 
4.8 E-4
Inhalation Slope Factor (mg/kg-day)-1: 
1.7 E+0
Oral Slope Factor (mg/kg-day)-1: 
1.7 E+0
Comments/References: 

US EPA 1987. IRIS Database: Nickel Subsulfide.

 

Note: This value was used as the basis of the No Significant Risk Level that was adopted in Title 22 California Code of Regulations, Section 12705, Subsection (b) for the purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65).

Air

Acute RELs

Acute REL (μg/m3): 
0.2
Species: 
Mouse
Acute REL Toxicologic Endpoint: 
Depressed antibody response
Acute REL Target Organs: 
Immune system
Last Acute REL Revision: 
2012
Acute Reference Exposure Levels Comments: 

Inhalation concentrations as micrograms Ni/m3.
OEHHA 2012. Nickel Reference Exposure Levels. Listed as Nickel & nickel compounds.

8-Hour RELs

8-Hour Inhalation REL (μg/m3): 
0.06
Last 8-Hour REL Revision: 
2012
8-Hour Reference Exposure Levels Comments: 

Inhalation concentrations as micrograms Ni/m3.
OEHHA 2013. Technical Support Document for Noncancer RELs, Appendix D1. Updated July 2014. Listed as Nickel & nickel compounds.

Chronic REL

Chronic Inhalation REL (μg/m3): 
0.014 (inhalation); 11 μg/kg BW-day (oral)
Chronic Target Organs: 
Inhalation: Respiratory system, hematologic system. Oral: Development
Human Data: 
No
Last Chronic REL Revision: 
2012
Chronic Reference Exposure Levels Comments: 

Inhalation concentrations as micrograms Ni/m3; oral dose as micrograms Ni/kg-day.
OEHHA 2012. Nickel Reference Exposure Levels. Listed as Nickel & nickel compounds (except nickel oxide for chronic inhalation exposures).

Proposition 65

Chemical Status

Cancer: 
Currently listed

Cancer

Listed as causing: 
Cancer
Date of Listing: 
10/01/1987
Basis for Listing: 
State's Qualified Experts

Safe Harbor Levels

Cancer
No Significant Risk Level (NSRL): 
0.4 µg/day

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