Hexamethylene Diisocyanate (Monomer)

CAS Number

822-06-0

Synonym

1,6-Diisocyanatohexane, 1,6-hexane diisocyanate, HMDI

Date Added

HDI Monomer

Cancer Potency Information

Latest Criteria: Reference Exposure Levels

Air

Acute RELs

Acute REL (μg/m3): 0.3
Species: Rodents
Acute REL Toxicologic Endpoint: Nasal epithelium lesions
Acute REL Target Organs: Respiratory system
Last Acute REL Revision: 09/06/2019
Acute Reference Exposure Levels Comments:

Notice of Adoption of Reference Exposure Levels for Hexamethylene Diisocyanate (Monomer and Polydiisocyanates)

8-Hour RELs

8-Hour Inhalation REL (μg/m3): 0.06
Last 8-Hour REL Revision: 09/06/2019
8-Hour Reference Exposure Levels Comments:

Notice of Adoption of Reference Exposure Levels for Hexamethylene Diisocyanate (Monomer and Polydiisocyanates)

Chronic REL

Chronic Inhalation REL (μg/m3): 0.03
Chronic Target Organs: Respiratory system
Human Data: Yes
Chronic Toxicologic Endpoint: HDI-induced asthma; accelerated decline in lung function
Last Chronic REL Revision: 09/06/2019
Chronic Reference Exposure Levels Comments:

Notice of Adoption of Reference Exposure Levels for Hexamethylene Diisocyanate (Monomer and Polydiisocyanates)