Actinomycin D

CAS Number

50-76-0

Synonym

dilactone actinomycin D acid, ACT, actinomycin A IV

Occurrence/Use

Medicine (antineoplastic)

Cancer Potency Information

Latest Criteria:	Proposition 65 NSRLs/MADLs
Inhalation Unit Risk (μg/cubic meter)-1:	2.5 E+0
Inhalation Slope Factor (mg/kg-day)-1:	8.7 E+3
Oral Slope Factor (mg/kg-day)-1:	8.7 E+3
Comments/References:	OEHHA 1992. Expedited Cancer Potency Values and Proposed Regulatory Levels for Certain Proposition 65 Carcinogens.

Proposition 65

Chemical Status

Cancer:	Currently listed
Reproductive Toxicity :	Currently listed

Cancer

Cancer - Listing Mechanism

Formally Required

Listed as causing :	Listed as causing: Cancer
Date of Listing:	02/22/2013

Reproductive Toxicity

Listed as causing:	Developmental Toxicity
Developmental Toxicity
Date of Listing:	10/01/1992
Basis for Listing :	Formally Required

Safe Harbor Levels

No Significant Risk Level (NSRL)

0.00008 µg/day

Cancer
Last NSRL/MADL Revision:	1992

Documents, Presentations, and Publications

Cancer:	Expedited Cancer Potency Values April 1, 1992

Comments

Basis for listing actinomycin D as known to the State to cause cancer changed from Labor Code to 'Formally Required to Be Labeled or Identified' effective February 22, 2013.