2,3,7,8-Tetrachlorodibenzo-p-dioxin and related compounds
CAS Number
1746-01-6Synonym
Dioxin, TCDD
Occurrence/Use
Byproduct of manufacture of chlorophenols, hexachlorophene, and herbicides; contaminant of the Agent Orange, PCBs, and pentachlorophenol; component of combustion, including waste incineration and tobacco smoke.
Soil Screening
| Last CHHSL revision: | 1/2005 |
|---|---|
| CHHSL Comments: |
For chemical-specific screening levels for use in assessing contaminated sites, please see HHRA Note 3 (DTSC HERO). https://www.dtsc.ca.gov/assessingrisk/humanrisk2.cfm |
Cancer Potency Information
| Inhalation Unit Risk (μg/cubic meter)-1: | 3.8 E+1 |
|---|---|
| Inhalation Slope Factor (mg/kg-day)-1: | 1.3 E+5 |
| Oral Slope Factor (mg/kg-day)-1: | 1.3 E+5 |
| Comments/References: |
OEHHA 2009. Air Toxics Hot Spots Program Technical Support Document for Cancer Potencies. Appendix B. Chemical-specific summaries of the information used to derive unit risk and cancer potency values. Updated 2011. |
Air
Hot Spots Unit Risk and Cancer Potency values
Unspeciated mixtures treated as 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746-01-6)
Acute RELs
| Last Acute REL Revision: | 12/01/2008 |
|---|
Chronic REL
| Chronic Inhalation REL (μg/m3): | 0.00004 (inhalation); 0.00001 μg/kg BW-day (oral) |
|---|---|
| Chronic Target Organs: | Inhalation and oral: Alimentary system (liver); reproductive system; development; endocrine system; respiratory system; hematologic system |
| Human Data: | No |
| Last Chronic REL Revision: | 12/01/2008 |
| Chronic Reference Exposure Levels Comments: |
OEHHA 2008. Technical Supporting Document for Noncancer RELs, Appendix D3
|
Proposition 65
Chemical Status
| Cancer: | Currently listed |
|---|---|
| Reproductive Toxicity : | Currently listed |
Cancer
| Listed as causing : | Listed as causing: Cancer |
|---|---|
| Date of Listing: |
Reproductive Toxicity
| Listed as causing: | Developmental Toxicity | Developmental Toxicity |
|---|---|
| Date of Listing: | |
| Basis for Listing : | Authoritative Bodies-US Environmental Protection Agency |
Safe Harbor Levels
| Cancer |
Water
California Public Health Goals Data
| Health Risk Category: | Carcinogenicity |
|---|---|
| Public Health Goal (mg/L): | 0.05 picograms/L (pg/L) |
| Public Health Goal - Download: |
|
| Cancer Risk at PHG: | 0.000001 |
| MCL value (mg/L): | 0.00000003 |
| Cancer Risk at MCL: | 0.0006 |
| Last PHG Revision : | 2010 |
| California PHG Comments: | The Public Health Goal for TCDD (Doxin) is 0.00005 nanograms/liter (ng/L) or 0.05 picograms/liter (pg/L). |