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2,3,7,8-Tetrachlorodibenzo-p-dioxin and related compounds

CAS Number

1746-01-6

Synonym

Dioxin, TCDD

Occurrence/Use

Byproduct of manufacture of chlorophenols, hexachlorophene, and herbicides; contaminant of the Agent Orange, PCBs, and pentachlorophenol; component of combustion, including waste incineration and tobacco smoke.

TCDD

Soil Screening

Last CHHSL revision: 
1/2005
CHHSL Comments: 

For chemical-specific screening levels for use in assessing contaminated sites, please see HHRA Note 3 (DTSC HERO). https://www.dtsc.ca.gov/assessingrisk/humanrisk2.cfm

Cancer Potency Information

Inhalation Unit Risk (μg/cubic meter)-1: 
3.8 E+1
Inhalation Slope Factor (mg/kg-day)-1: 
1.3 E+5
Oral Slope Factor (mg/kg-day)-1: 
1.3 E+5
Comments/References: 

OEHHA 2009. Air Toxics Hot Spots Program Technical Support Document for Cancer Potencies. Appendix B. Chemical-specific summaries of the information used to derive unit risk and cancer potency values. Updated 2011.

Air

Acute RELs

Last Acute REL Revision: 
12/01/2008
Hot Spots Unit Risk and Cancer Potency values: 

Unspeciated mixtures treated as 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746-01-6)

Chronic REL

Chronic Inhalation REL (μg/m3): 
0.00004 (inhalation); 0.00001 μg/kg BW-day (oral)
Chronic Target Organs: 
Inhalation and oral: Alimentary system (liver); reproductive system; development; endocrine system; respiratory system; hematologic system
Human Data: 
No
Last Chronic REL Revision: 
12/01/2008
Chronic Reference Exposure Levels Comments: 

Proposition 65

Chemical Status

Cancer: 
Currently listed
Reproductive Toxicity: 
Currently listed

Cancer

Listed for: 
Cancer
Date of Listing: 
01/01/1988
Basis for Listing: 
State's Qualified Experts

Reproductive Toxicity

Listed for: 
Developmental Toxicity
Developmental Toxicity
Date of Listing: 
04/01/1991
Basis for Listing: 
Authoritative Bodies-US Environmental Protection Agency

Safe Harbor Levels

Cancer
No Significant Risk Level (NSRL): 
0.000005 µg/day

Water

California Public Health Goals Data

Health Risk Category: 
Carcinogenicity
Public Health Goal (mg/L): 
0.05 picograms/L (pg/L)
Public Health Goal - Download: 
Cancer Risk at PHG: 
0.000001
MCL value (mg/L): 
0.00000003
Cancer Risk at MCL: 
0.0006
Last PHG Revision : 
2010
California PHG Comments: 
The Public Health Goal for TCDD (Doxin) is 0.00005 nanograms/liter (ng/L) or 0.05 picograms/liter (pg/L).