1,3-Butadiene

CAS Number

106-99-0

Synonym

Vinylethylene; Erthrene; Bivinyl; Divinyl

Occurrence/Use

Polymer component in production of synthetic rubber, plastic, and fuel; chemical intermediate (nylon); component of tobacco smoke

Cancer Potency Information

Inhalation Unit Risk (μg/cubic meter)-1: 1.7 E-4
Inhalation Slope Factor (mg/kg-day)-1: 6.0 E-1
Oral Slope Factor (mg/kg-day)-1: 6.0 E-1
Comments/References:

OEHHA 2009. Air Toxics Hot Spot Program Technical Support Document for Cancer Potencies. Appendix B. Chemical-specific summaries of the information used to derive unit risk and cancer potency values. Updated 2011.

Air

Acute RELs

Acute REL (μg/m3): 660
Species: Mouse
Acute REL Toxicologic Endpoint: Development (low male fetal weight)
Acute REL Target Organs: Development
Severity: Severe
Last Acute REL Revision: 2013
Acute Reference Exposure Levels Comments:

OEHHA 2013. Reference Exposure Levels for 1,3-Butadiene

8-Hour RELs

8-Hour Inhalation REL (μg/m3): 9
Last 8-Hour REL Revision: 2013
8-Hour Reference Exposure Levels Comments:

OEHHA 2013. Technical Support Document for Noncancer RELs, Appendix D1. Updated July 2014.

Chronic REL

Chronic Inhalation REL (μg/m3): 2
Chronic Target Organs: Reproductive system
Human Data: No
Last Chronic REL Revision: 2013
Chronic Reference Exposure Levels Comments:

OEHHA 2013. Reference Exposure Levels for 1,3-Butadiene

Proposition 65

Chemical Status

Cancer: Currently listed
Reproductive Toxicity : Currently listed

Cancer

Cancer - Listing Mechanism
State's Qualified Experts
Listed as causing : Listed as causing: Cancer
Date of Listing:

Reproductive Toxicity

Date of Listing
Listed as causing: Developmental Toxicity Male Reproductive Toxicity Female Reproductive Toxicity
Developmental Toxicity
Date of Listing:
Basis for Listing : Authoritative Bodies-National Institute for Occupational Safety and Health Authoritative Bodies-US Environmental Protection Agency
Male Reproductive Toxicity
Date of Listing:
Basis for Listing : Authoritative Bodies-National Institute for Occupational Safety and Health Authoritative Bodies-US Environmental Protection Agency
Female Reproductive Toxicity
Basis for Listing: Authoritative Bodies-National Institute for Occupational Safety and Health Authoritative Bodies-US Environmental Protection Agency

Safe Harbor Levels

No Significant Risk Level (NSRL)
0.4 µg/day
Cancer

Documents, Presentations, and Publications

Reproductive Toxicity:

Public notices related to this chemical