Meeting Synopsis and Slide Presentations Carcinogen Identification Committee Meeting Held on October 12, 2011

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A meeting of the Proposition 651 Carcinogen Identification Committee (CIC) was held on October 12, 2011, at the California Environmental Protection Agency Headquarters Building in Sacramento, California.  The Committee considered the listing of Tris(1,3-dichloro-2-propyl) phosphate and fluoride and its salts as known to the state cause cancer.  The Committee also provided OEHHA with its advice concerning the relative priority of 39 chemicals for possible hazard identification material preparation.  In addition, the Committee discussed procedures for public comment presentations, committee discussions and committee voting.  Following is a summary of that meeting. 

SUMMARY OF THE LISTING DECISION FOR TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE (TDCPP) AND FLUORIDE AND ITS SALTS

Following a staff presentation, comments from the public and committee discussion, the CIC determined on a 5-1 vote that TDCPP has been clearly shown to cause cancer.  The CIC determined on a 6-0 vote that fluoride and its salts has not been clearly shown to cause cancer.

Follow these links to the slide presentations made at the meeting by staff of the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) and members of the public:

SUMMARY OF CHEMICAL PRIORITIZATION DISCUSSION
The CIC recommended that 7 of the 39 chemicals referred to them for advice and consultation be placed in the ‘high’ priority group, 21 chemicals be placed in the ‘medium’ priority group, and the remaining 11 be placed in the ‘low’ priority group (see table below for specific suggestions concerning chemical priority assignments.)  Follow this link to the slide presentation made by OEHHA. For more information on the prioritization process for chemicals, please click here.

 

High

Medium

Low

Acetominophen

Abacavir and its salts

Chloropicrin

Butyl benzyl phthalate

Bisphenol A

Dicloran

C.I. Disperse Yellow 3

Butylated hydroxytoluene

Hexythiazox

Coumarin

Chloroalkyl ethers

Hydralazine and its salts

Dibenzanthracenes and Dibenz[a,c]anthracene

Clodinafop-propargyl

Isophosphamide

2,4-Dichlorophenoxyacetic acid and its salts and esters

Dapsone

Metofluthrin

N-Methyl-N-nitroso-1-alkylamines and N-methyl-N-nitroso-1-octanamine and N-methyl-N-nitroso-1-decanamine and N-methyl-N-nitroso-1-dodecanamine and N methyl-N-nitroso-1-tetradecanamine

3,3'-Dichlorobenzidine-based compounds metabolized to 3,3'-dichlorobenzidine

N-Methylpyrrolidone

 

Dinitroaniline pesticides* (prodiamine and trifluralin)

6-Nitrobenzimidazole

 

Entecavir

Pentachloronitrobenzene

 

Flonicamid

Pivalolactone

 

Fluazinam

Pyraflufen ethyl

  Mixtures containing pentabromochlorocyclohexane  
  N-Nitroso-N-methylaniline  
  Pimecrolimus  
  Raloxifen and its salts  
  Stavudine  
  Thiophanate methyl  
  Topoisomerase II Inhibitors  
  Triazole antifungal agents  
  2,4,6-Trimethylaniline and its salts  

 

Tris(2-ethylhexyl) phosphate

 

*Public presentation made on pendimethalin, Frederick Hess, Ph.D., BASF Chemical Company

SUMMARY OF THE COMMITTEE MEETING PROCEDURES DISCUSSION

Following the staff presentation and committee discussion, the CIC advised that they generally prefer the following guidelines:

  • Limiting public comments to five minutes per speaker with the Chair retaining discretion to extend the time when speakers are addressing complex scientific issues.  Time responding to clarifying questions from the committee is not included in the 5 minute limit.
  • Not allowing speakers to cede time to each other.
  • Keeping related speakers together.
  • Announce time limits in advance of the meeting.
  • Continuing to vote via a show of hands that are tallied and announced by the Chair.

Click here for meeting transcript.


1 The Safe Drinking Water and Toxic Enforcement Act of 1986, codified at Health and Safety Code section  25249.5 et seq.