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Meeting of the Developmental and Reproductive Toxicant Identification Committee

Wednesday, March 19, 2014,
Sierra Hearing Room, 10:00 am
1001 I Street
Cal/EPA Headquarters Building, Sacramento

A meeting of the Proposition 651 Developmental and Reproductive Toxicant Identification Committee (DARTIC) was held on March 19, 2014, at the California Environmental Protection Agency Headquarters Building in Sacramento, California.  The Committee reconsidered the listing of six chemicals as known to the state to cause reproductive toxicity.  The six chemicals weren-butyl glycidyl ether, diglycidyl ether, phenyl glycidyl ether, methyl n-butyl ketone, methyl isopropyl ketone and α-methyl styrene.The Committee also discussed the tabulation of epidemiological and animal data in hazard identification documents, and heard a staff update on various Proposition 65 activities. 

The meeting will be available via webcast. The URL for the webcast is: http://calepa.ca.gov/Broadcast/.

Agenda

  1. WELCOME AND OPENING REMARKS
    Dr. George Alexeeff, Director, Office of Environmental Health Hazard Assessment (OEHHA)
  2. RECONSIDERATION OF LISTING OF CHEMICALS LISTED VIA THE LABOR CODE AS KNOWN TO THE STATE TO CAUSE REPRODUCTIVE TOXICITY
    Introductory comments – Carol Monahan-Cummings, Chief Counsel, and Dr. James Donald, Chief of Reproductive Toxicology and Epidemiology Section, OEHHA
  • n-Butyl glycidyl ether
    • Staff presentation – Dr. Francisco Moran, OEHHA
    • Public comments*
    • Committee discussion and decision
  • Diglycidyl ether
    • Staff presentation – Dr. Francisco Moran, OEHHA
    • Public comments*
    • Committee discussion and decision
  • Phenyl glycidyl ether
    • Staff presentation – Dr. Francisco Moran, OEHHA
    • Public comments*
    • Committee discussion and decision
  • Methyl n-butyl ketone
    • Staff presentation – Dr. Francisco Moran, OEHHA
    • Public comments*
    • Committee discussion and decision
  • Methyl isopropyl ketone
    • Staff presentation – Dr. Francisco Moran, OEHHA
    • Public comments*
    • Committee discussion and decision
  • α-Methyl styrene
    • Staff presentation – Dr. Francisco Moran, OEHHA
    • Public comments*
    • Committee discussion and decision
  1. Committee Discussion on Tabulation of Data from Epidemiological and Animal Data in Hazard Identification Documents
    • Introduction – Dr. Gold

    • Public comments*

    • Committee discussion
  1. Update of Section 27000 List of Chemicals Which Have Not Been Adequately Tested as Required
    Carol Monahan-Cummings, Chief Counsel, OEHHA
  2. STAFF UPDATES
    • Chemical listings (Cynthia Oshita, Proposition 65 Implementation, OEHHA)
    • Proposition 65 litigation (Carol Monahan-Cummings, Chief Counsel, OEHHA)
  1. SUMMARY OF COMMITTEE ACTIONS
    Dr. George Alexeeff, Director, OEHHA

* Generally public comments should be limited to 5 minutes, which may be changed if time allows and at the discretion of the chair.

 

Summary of the Committee Decisions: 

Following presentations by Office of Environmental Health Hazard Assessment (OEHHA) staff, public comments and committee discussions, the DARTIC made the following decisions:

The following chemicals will be removed from the Proposition 65 list as known to cause reproductive toxicity:
  • n-butyl glycidyl ether
  • diglycidyl ether
  • phenyl glycidyl ether
  • methyl isopropyl ketone
  • α-methyl styrene

The DARTIC deferred its decision on methyl n-butyl ketone and asked OEHHA to investigate the availability of the original animal data from a developmental study of the chemical that was published by the National Institute for Environmental Health Sciences.  The DARTIC asked OEHHA to report back at its next meeting.  In the interim, methyl n-butyl ketone will remain on the Proposition 65 list.

Committee Discussion on Tabulation of Epidemiological and Animal Data in Hazard Identification Documents

The DARTIC discussed draft templates for tabulating data from epidemiology and animal studies in hazard identification documents, and the public comments received on the draft templates. 

Several members stated that they liked the draft templates.  Members made suggestions for additional information that could be included in future tables in hazard identification documents:

  • more detailed information on statistical analyses and statistical study power
  • hyperlinks to reference materials within the electronic file of the hazard identification document (in both the tables and the text)

In addition, there was a suggestion to include graphical presentations of outcomes across studies as additional information to complement the tables.

Lastly, a member suggested that the National Toxicology Program (NTP) be asked to make a presentation to the DARTIC on the data tools the NTP is developing for use in evaluating studies of chemical toxicities.

Update of the Section 27000 List of Chemicals Which Have Not Been Adequately Tested as Required

The DARTIC was asked to consider the addition of 16 chemicals to and the removal of six other chemicals from the Section 27000 list of Chemicals That Have Not Been Adequately Tested as Required.  The DARTIC voted unanimously to add the 16 chemicals as identified by the U.S. Environmental Protection Agency to the Section 27000 list.  The DARTIC also voted unanimously to remove the 6 chemicals as identified by the U.S. EPA and the Department of Pesticide Regulation from the Section 27000 list.

1 The Safe Drinking Water and Toxic Enforcement Act of 1986, codified at Health and Safety Code section 25249.5 et seq.

 

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