Comment Period - Prioritization: 27 Chemicals Identified for Consultation with the Proposition 65 Carcinogen Identification Committee
The CIC meeting will be held in the Sierra Hearing Room at the Cal/EPA Headquarters building, 1001 I Street in Sacramento, California. The meeting will begin each day at 10:00 a.m. and will last until 5:00 p.m. on Tuesday and until all business is conducted or until 5:00 p.m. on Wednesday. The agenda for the two-day meeting will be provided in a future public notice published in advance of the meeting.
This notice announces the beginning of the public comment period on the 27 chemicals listed below. These chemicals will be discussed at the next meeting of the Proposition 65 Carcinogen Identification Committee (CIC). The CIC is the state’s qualified experts on carcinogenicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The CIC’s next meeting is scheduled for Tuesday and Wednesday, September 21 and 22, 2010, when the CIC will provide OEHHA with advice on the prioritization of these chemicals for possible preparation of hazard identification materials. At a later date, OEHHA will select chemicals for preparation of hazard identification materials and announce those decisions in a separate notice. No listing decisions will be made for these chemicals at the September 21 and 22 meetings.
The Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of Proposition 65. OEHHA has screened several hundred chemicals in the OEHHA tracking database for evidence of cancer hazard as well as potential human exposure in California. This initial screening follows the procedure described in the 2004 “Process for Prioritizing Chemicals for Consideration under Proposition 65 by the State’s Qualified Experts”.
OEHHA applied both a human and animal data screen to roughly 75 percent of the candidate chemicals in the tracking database. These screens were discussed at the November 17, 2007 and November 5, 2008 meetings of the CIC. OEHHA conducted a preliminary toxicological evaluation for the chemicals that passed the two screens. Based on this preliminary evaluation, OEHHA identified the 27 chemicals listed below for committee discussion, advice and possible preparation of hazard identification materials for consideration at future CIC meetings.
The 27 chemicals are:
- Acephate
- Alpha-methyl styrene (1-methyl-1-phenylethylene)
- Amitraz
- Atrazine
- 2-Biphenylamine and its salts
- Budesonide
- 4-Chloro-m-phenylenediamine
- C.I. Acid Orange 3
- Ciprofibrate
- Clomiphene and its salts
- Decabromodiphenyl ether (DecaBDE; decabromobiphenyl oxide)
- Decalin
- 2,6-Dichloro-p-phenylenediamine
- Furfural
- Gentian Violet
- 4-Hydroxymethyl, 4-Methyl, and 4-Hydroxy Benzenediazonium and their salts
- Isoniazid
- Malathion
- 7-Methylbenz[a]anthracene
- N-Methyl-N-formylhydrazine
- Methylphenidate and its salts
- Omeprazole and its salts
- Pantoprazole and its salts
- Perfluorooctane sulfonate (PFOS) and its salts and transformation and degradation precursors
- Phosmet
- Quinoxaline-1,4-dioxide compounds and Desoxycarbadox
- Rabeprozole and its salts
Copies of the summaries of available scientific information on the chemicals and related attachments are available on OEHHA’s web site above or may be requested by calling (916) 445-6900.
Interested parties may provide comment on the extent of the scientific evidence pertaining to the selection and priority of any of these chemicals for possible preparation of hazard identification materials. OEHHA must receive comments and any supporting documentation by 5:00 p.m. on Tuesday, August 31, 2010. The comment period is abbreviated by one week to allow for sufficient time for the CIC members to review comments along with the summaries and related attachments prior to the meeting. We encourage you to submit comments in electronic form, rather than in paper form. Comments transmitted by e-mail should be addressed to sam.delson@oehha.ca.gov. Comments submitted in paper form may be mailed, faxed, or delivered in person to the addresses below:
Mailing Address: Sam Delson
Office of Environmental Health Hazard Assessment
P.O. Box 4010, MS-19B
Sacramento, California 95812-4010
Fax: (916) 323-8803
Street Address: 1001 I Street
Sacramento, California 95814
OEHHA will organize and index the comments received and forward the information to the CIC members prior to the September 21 and 22 meetings at which the chemicals will be considered.