Request for Relevant Information on the Reproductive Toxicity (Developmental Toxicity Endpoint) of Cannabis and Cannabis-Related Chemicals

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of Proposition 65^[1].  The Developmental and Reproductive Toxicant Identification Committee (DARTIC) of OEHHA’s Science Advisory Board serves as the state’s qualified experts and renders an opinion about whether a chemical has been clearly shown to cause reproductive toxicity^[2]. The chemicals identified by the DARTIC are added to the Proposition 65 list.

OEHHA has selected the chemicals below for the DARTIC’s review for possible listing under Proposition 65 as causing reproductive toxicity (developmental toxicity endpoint).  OEHHA is initiating the development of hazard identification materials on these chemicals.

Chemicals Selected for Preparation of Reproductive Toxicity (Developmental Toxicity Endpoint) Hazard Identification Materials

Hazard identification materials for these chemicals will be presented at a future meeting of the DARTIC for Committee consideration of possible listings of the chemicals under Proposition 65. 

By this notice, OEHHA is giving the public an opportunity to provide information relevant to the assessment of the evidence of developmental toxicity for cannabis (marijuana), marijuana smoke, cannabis extracts and Δ-9-tetrahydrocannabinol (THC).  Interested parties or members of the public wishing to provide such information should submit it in accordance with the instructions given below. 

The publication of this notice marks the start of a 45-day data call-in period, ending on Monday, April 29, 2019.  The information received during this period will be reviewed and considered by OEHHA as it prepares the hazard identification materials on these chemicals.

Hazard identification materials are made available to the public for comment prior to the DARTIC’s consideration of the chemical(s) for possible listing.  The availability of the hazard identification materials will be announced in the California Regulatory Notice Register and on OEHHA’s website.  Public comments received on these materials will be sent to the DARTIC for its consideration prior to the meeting at which the chemical(s) are considered for listing.  The time, date, location, and agenda of the DARTIC meeting where a chemical will be considered for listing will be published in the California Regulatory Notice Register and posted on OEHHA’s website.

We encourage you to submit relevant information responsive to this request in electronic form, rather than in paper form.  Comments may be submitted electronically through our website at https://oehha.ca.gov/comments.  Comments submitted in paper form can be mailed, faxed, or delivered in person to the addresses below:

Mailing Address: 

Julian Leichty
Office of Environmental Health Hazard Assessment
Proposition 65 Implementation
P.O. Box 4010, MS-12B
Sacramento, California 95812-4010
Fax: (916) 323-2265
Street Address:  

1001 I Street
Sacramento, California 95814

In order to be considered at this point in the process, the relevant information must be received at OEHHA by 5:00 p.m. on Monday, April 29, 2019.

Link to Public Comments

• Comment Submissions - Request for Relevant Information on the Reproductive Toxicity (Developmental Toxicity Endpoint) of Cannabis and Cannabis-Related Chemicals

Footnotes and References