Bisphenol S (BPS) Added to the Proposition 65 List for Reproductive Toxicity
Bisphenol S: Developmental Toxicant
Effective December 8, 2025, the Office of Environmental Health Hazard Assessment (OEHHA) has added the developmental toxicity endpoint to the reproductive toxicity listing of bisphenol S (BPS) under Proposition 65. This addition was done via the “State’s Qualified Experts” listing mechanism, based on the Developmental and Reproductive Toxicant Identification Committee’s (DARTIC) determination that this chemical was clearly shown to cause developmental toxicity. BPS was first placed on the Proposition 65 list for reproductive toxicity on December 29, 2023, based on the female reproductive endpoint. The male reproductive endpoint was added on January 3, 2025.
A summary and agenda of the 2025 DARTIC meeting can be found in the Downloads section below.
Bisphenol S: Male Reproductive Toxicant
Effective January 3, 2025, the Office of Environmental Health Hazard Assessment (OEHHA) has added the male reproductive toxicity endpoint to the listing of bisphenol S (BPS) on the Proposition 65 list for reproductive toxicity. This listing was done via the “State’s Qualified Experts” mechanism, based on the Developmental and Reproductive Toxicant Identification Committee’s (DARTIC) determination that this chemical was clearly shown to cause male reproductive toxicity. BPS was first placed on the Proposition 65 list for reproductive toxicity, based on the female reproductive endpoint, on December 29, 2023.
A summary and agenda of the 2024 DARTIC meeting can be found in the Downloads section below.
Bisphenol S: Female Reproductive Toxicant
Effective December 29, 2023, the Office of Environmental Health Hazard Assessment (OEHHA) has added bisphenol S (BPS) to the Proposition 65 list as a reproductive toxicant (female reproductive endpoint). This listing was done via the “State’s Qualified Experts” mechanism, based on the Developmental and Reproductive Toxicant Identification Committee’s (DARTIC) determination that this chemical was clearly shown to cause female reproductive toxicity.
The warning requirement for significant exposures to BPS took effect on December 29, 2024.
A summary and agenda of the 2023 DARTIC meeting can be found in the Downloads section below.
Data Call-In
On March 4, 2022, OEHHA started a data call-in process to solicit information on BPS from the public.
Link to Public Comments
- Comment Submissions - Announcement of the Developmental and Reproductive Toxicant Identification Committee Meeting
- Comment Submissions - Announcement of the Developmental and Reproductive Toxicant Identification Committee Meeting Scheduled for December 12, 2023
- Comment Submissions - Request For Relevant Information On The Reproductive Toxicity Of Bisphenol S (BPS)