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N-Carboxymethyl-N-nitrosourea Listed as Known to the State of California to Cause Cancer, and Cyclohexanol and 2,4-DP Delisted from the List of Chemicals as Known to the State of California to Cause Reproductive Toxicity

Chemical Listed Effective January 25, 2002 as Known to the State of California to Cause Cancer

Chemicals Delisted Effective January 25, 2002 from the List of Chemicals as Known to the State of California to Cause Reproductive Toxicity

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding N-carboxymethyl-N-nitrosourea to the list of chemicals known to the State to cause cancer and removing cyclohexanol and 2,4-DP (dichloroprop) from the list of chemicals known to the State to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of N-carboxymethyl-N-nitrosourea and the delisting of cyclohexanol and 2,4-DP (dichlroprop) are effective January 25, 2002.

N-carboxymethyl-N-nitrosourea (CAS # 60391-92-6) was considered for listing under Proposition 65 by the "state's qualified experts" (the Carcinogen Identification Committee (CIC) of the OEHHA Science Advisory Board) at a public meeting held on December 18, 2001. The CIC determined that N-carboxymethyl-N-nitrosourea was clearly shown through scientifically valid testing according to generally accepted principles to cause cancer. Regulations governing the listing of chemicals by the "state's qualified experts" mechanism are published in Title 22, California Code of Regulations (22 CCR), Section 12305(a)(1).

Cyclohexanol (CAS #108-93-0) and 2,4-DP (dichloroprop) (CAS # 120-36-5) were considered by the "state's qualified experts" (the Developmental and Reproductive Toxicant (DART) Identification Committee of the OEHHA Science Advisory Board) for removal from the list of chemicals known to the State to cause reproductive toxicity at a public meeting held on December 17, 2001. The DART Identification Committee determined that cyclohexanol and 2,4-DP (dichloroprop) should be removed from the list of chemicals known to the State to cause reproductive toxicity.

The reader is directed to the Notice to Interested Parties published in the October 5, 2001, issue of the California Regulatory Notice Register (Register 01, No. 40-Z) for the supporting documentation which the CIC relied upon in making its determination that N-carboxymethyl-N-nitrosourea has been clearly shown to cause cancer. The reader is directed to another Notice to Interested Parties also published in the same issue of the California Regulatory Notice Register for the supporting documentation which the DART Identification Committee relied upon in its reconsideration of listing of cyclohexanol and 2,4-DP (dichloroprop).

A complete, updated chemical list is available from the download area below.

In summary, the following chemical added to the Proposition 65 chemical list as known to the State to cause cancer:

Chemical CAS No. Listing Mechanism*
N-Carboxymethyl-N-nitrosourea 60391-92-6 SQE

*Listing mechanism:
SQE - "state's qualified experts" mechanisms (22 CCR Section 12305(a)(1))

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