Chemicals Listed as Known to the State to Cause Reproductive Toxicity: 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) (CAS No. 72-55-9) and Nitrobenzene (CAS No. 98-95-3)

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The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) (CAS No. 72-55-9) and nitrobenzene (CAS No. 98-95-3) to the list of chemicals known to the State to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and nitrobenzene is effective March 30, 2010.

1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) (CAS No.72-55-9) is being listed as a chemical known to the State of California to cause developmental and male reproductive toxicity. Nitrobenzene (CAS No. 96-95-3) is being listed as a chemical known to the State of California to cause male reproductive toxicity. The listing of these chemicals is based on formal identification by an authoritative body (the U.S. Environmental Protection Agency (U.S. EPA)), that the chemical 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) causes developmental and male reproductive toxicity and the chemical nitrobenzene causes male reproductive toxicity. The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 27, Cal. Code of Regs., section 25306.

The reader is directed to the Notice of Intent to List 1,1-Dichloro-2,2-bis(p-chloro-phenyl)ethylene (DDE) (CAS No.72-55-9) and Nitrobenzene (CAS No. 96-95-3) published in the January 29, 2010 issue of the California Regulatory Notice Register (Register 2010, No. 5 Z) for the documentation supporting OEHHA’s determination that the criteria for administrative listing have been satisfied for these chemicals.

OEHHA analyses of dose-response data to establish the maximum allowable dose levels (MADLs) for 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and nitrobenzene under Proposition 65 have not yet been conducted. The priority status for the development of such analyses will be announced in a future OEHHA Proposition 65 Status Report for Safe Harbor Levels.

A complete, updated Proposition 65 list is available here. The table below summarizes the changes made today to the Proposition 65 list.


CAS Number

Toxicological Endpoint Listing Mechanism
1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) 72-55-9 developmental, male reproductive toxicity AB
Nitrobenzene 98—95-3 male reproductive toxicity AB

If you would like to sort the list by CAS number or date, please download the list as an Excel spreadsheet below, hyphenated and with the associated Safe Harbor Levels here. You can then sort the list by date, CAS number or chemical name using MS Excel.