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Chemicals Listed Effective July 1, 2008 as Known to the State of California to Cause Cancer: benthiavalicarb-isopropyl, mepanipyrim, pirimicarb and resmethrin

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding benthiavalicarb-isopropyl (CAS No. 177406-68-7), mepanipyrim (CAS No. 110235-47-7), pirimicarb (CAS No. 23103-98-2) and resmethrin (CAS No. 10453-86-8) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing date of the four chemicals is effective July 1, 2008.

Benthiavalicarb-isopropyl (CAS No. 177406-68-7), mepanipyrim (CAS No. 110235-47-7), pirimicarb (CAS No. 23103-98-2) and resmethrin (CAS No. 10453-86-8) are being listed as chemicals known to the State of California to cause cancer. The listing of the four chemicals is based on formal identification by an authoritative body (i.e., the U.S. Environmental Protection Agency (U.S. EPA)), that the chemicals cause cancer. The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 22, Cal. Code of Regs., section 12306.

The reader is directed to the Notice of Intent to List Benthiavalicarb-isopropyl (CAS No. 177406-68-7), Mepanipyrim (CAS No. 110235-47-7), Pirimicarb (CAS No. 23103-98-2) and Resmethrin (CAS No. 10453-86-8) published in the May 2, 2008 issue of the California Regulatory Notice Register (Register 2008, No. 18 Z) for the documentation supporting OEHHA’s determination that the criteria for administrative listing have been satisfied for this chemical.

A complete, updated Proposition 65 list is available below.

Chemicals Listed Effective July 1, 2008

Chemical CAS No. Toxicological Endpoint Mechanism1
Benthiavalicarb-isopropyl 177406-68-7 cancer AB
Mepanipyrim 110235-47-7 cancer AB
Pirimicarb 23103-98-2 cancer AB
Resmethrin 10453-86-8 cancer AB

OEHHA analysis of dose-response data to establish the no significant risk levels (NSRLs) for benthiavalicarb-isopropyl (CAS No. 177406-68-7), mepanipyrim (CAS No. 110235-47-7), pirimicarb (CAS No. 23103-98-2) and resmethrin (CAS No. 10453-86-8) under Proposition 65 has not yet been conducted. OEHHA anticipates proposing a “No Significant Risk Level” (NSRL) for resmethrin within a year of its listing. In the case of benthiavalicarb-isopropyl and mepanipyrim, which are not currently registered for use in the U.S., and pirimicarb, which is not currently registered for use in California, OEHHA does not anticipate proposing NSRLs on these chemicals within the next few years.

Any member of the public who would like OEHHA to develop NSRLs for benthiavalicarb-isopropyl, mepanipyrim or primicarb may submit a request to OEHHA in writing. Requests may be submitted to:

Proposition 65 Office
Office of Environmental Health Hazard Assessment
P.O. Box 4010
Sacramento, California 95812-4010

Fax No.: (916) 323-8803

E-mail: P65Public.Comments@oehha.ca.gov

Footnotes and References

1 Listing mechanism: AB – “authoritative bodies” mechanism (Title 22, Cal. Code of Regs. section 12306)