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Chemical Listed Effective November 12, 2010 as Known to the State Of California to Cause Reproductive Toxicity: Methyl Isocyanate

The Office of Environmental Health Hazard Assessment (OEHHA) is adding a chemical to the list of chemicals known to the State to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 1). The chemical is methyl isocyanate (MIC) (CAS No. 624-83-9). Methyl isocyanate is listed effective November 12, 2010.

Methyl isocyanate (MIC) (CAS No. 624-83-9) was considered by the Developmental and Reproductive Toxicant Identification Committee (DARTIC) in its official capacity as the “state’s qualified experts” at a public meeting held on October 21, 2010. The DARTIC determined that MIC was clearly shown, through scientifically valid testing according to generally accepted principles, to cause developmental and female reproductive toxicity. Regulations governing the criteria for listing of chemicals by the DARTIC are set out in Title 27, California Code of Regulations, section 25305(b)(1).

A complete, updated chemical list is published in this issue of the California Regulatory Notice Register and is available on the OEHHA website.

In summary, the following chemical is being listed under Proposition 65 as known to the State to cause:

Reproductive toxicity

Chemical CAS No. Toxicological Endpoints Listing Mechanism2
Methyl isocyanate (MIC) 624-83-9 Developmental toxicity
Female reproductive toxicity		 SQE

Footnotes and References

1Health and Safety Code section 25249.5 et seq.
2Listing mechanism: SQE – “state’s qualified experts” mechanism (Title 27 Cal. Code of Regs., section 25305(b)(1)).