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Chemical Listed Effective May 21, 2010 as Known to the State of California to Cause Reproductive Toxicity: N,N-Dimethylacetamide

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding N,N-Dimethylacetamide (CAS No. 127-19-5) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65).  The listing of N,N-dimethylacetamide is effective May 21, 2010. 

Health and Safety Code section 25249.8(a) requires that substances identified in Labor Code section 6382(d) as causing reproductive toxicity be included on the Proposition 65 list.  Labor Code section 6382(d) references chemicals within the scope of the federal Hazard Communication Standard that are identified as reproductive toxicants (Title 29, Code of Federal Regulations (CFR), section1910.1200, Toxic and Hazardous Substances, Occupational Safety and Health Administration).  Chemicals are listed under Proposition 65 if they are identified as causing developmental or reproductive toxicity in the latest edition of the American Conference of Governmental Industrial Hygienists (ACGIH) “Threshold Limit Values”. (Title 29, CFR, section 1910.1200(d)(3)).

The basis for the listing of N,N-dimethylacetamide (CAS No. 127-19-5) was described in a public notice published in the June 12, 2009 issue of the California Regulatory Notice Register  (Register 2009, No. 24-Z).  The title of the notice was “Request For Comments on Chemicals Proposed For Listing By the Labor Code Mechanism (reproductive and developmental toxicants)”.  The publication of the notice initiated a 30-day public comment period that closed on July 13, 2009.

OEHHA analysis of dose-response data to establish the maximum allowable dose level (MADL) for N,N-dimethylacetamide under Proposition 65 has not yet been conducted.  The priority status for the development of such analysis will be announced in a future OEHHA Proposition 65 Status Report for Safe Harbor Levels.

Chemical Listed as Known to Cause Reproductive Toxicity: N,N-Dimethylacetamide

Chemical
CAS No.
Toxicological Endpoint
Listing Mechanism
N,N-Dimethylacetamide
127-19-5
developmental
LC

Footnotes and References

Health and Safety Code, section 25249.5 et seq.