Candidate for Listing via the Authoritative Bodies Mechanism Found Not to Meet the Formal Identification Criteria: Tetraconazole
On December 2, 2011, the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) issued a Notice of Intent to List Tetraconazole (CAS No. 112281-77-3) as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 19861 (Register 2011, No. 48-Z). This action was proposed under the authoritative bodies listing mechanism,2 based on a report published by the U.S. Environmental Protection Agency (U.S. EPA) on tetraconazole, entitled Cancer Assessment Document, Evaluation of the Carcinogenic Potential of Tetraconazole, that concluded tetraconazole is “likely to be carcinogenic to humans” (U.S. EPA, 2000).
In 2013, U.S. EPA re-evaluated the cancer classification of tetraconazole, and issued a report entitled Cancer Assessment Document, Re-Evaluation of the Carcinogenic Potential of Tetraconazole (U.S. EPA, 2013), that concludes tetraconazole is “not likely to be carcinogenic to humans at levels that do not cause increased cell proliferation in the liver.”
Therefore, tetraconazole no longer meets the formal identification criteria specified in Title 27, California Code of Regulations, section 25306(d). OEHHA will not proceed with the proposed listing of tetraconazole via the authoritative bodies mechanism at this time.
In 2011, the Carcinogen Identification Committee (CIC) recommended that the triazole antifungal agents be assigned a medium priority for future consideration for listing under Proposition 65 as causing cancer3. Since tetraconazole is a triazole antifungal agent, it will be considered by the CIC as part of its future consideration of triazole antifungal agents. OEHHA has not initiated the development of hazard identification materials on these compounds. At such time as work on the triazole antifungal agents is initiated, OEHHA will make a request for submission of relevant scientific information on the entire class of chemicals, including tetraconazole.
- Tetraconazole