Comments on DPR’s Risk Characterization and Exposure Assessment Documents for 4 Neonicotinoids (Acetamiprid, Clothianidin, Dinotefuran, and Thiamethoxam)

Under the authority of California Food and Agricultural Code Section 11454.1, the Office of Environmental Health Hazard Assessment (OEHHA) conducts scientific peer review of human health risk assessments prepared by the Department of Pesticide Regulation (DPR).  DPR reports the risk assessment in two documents:

• The Risk Characterization Document (RCD), which summarizes the toxicology database of the chemical; discusses hazard identification and dose-response analyses; assesses dietary exposure, when appropriate; and characterizes the risk associated with the various exposure scenarios (dietary, occupational, residential, and aggregate exposures).
• The Human Exposure Assessment Document (EAD), which describes non-dietary exposure scenarios and estimates exposure levels of workers and residents.

This report is a review of the draft RCDs and draft EADs for non-agricultural, non-production outdoor uses and post-application exposures to the pesticides acetamiprid, clothianidin, dinotefuran, and thiamethoxam provided by DPR (dated and received January 30, 2025). The draft EADs were included appendices in the draft RCDs.