Request for Information on N‑methyl‑N‑nitroso‑1‑alkylamines, N-methyl-N-nitroso-1-octanamine, -decanamine, ‑dodecanamine, and ‑tetradecanamine

Mar 23, 2013

Chemicals Selected by OEHHA for Consideration for Listing by the Carcinogen Identification Committee and Request for Relevant Information on the Carcinogenic Hazards of: N‑methyl‑N‑nitroso‑1‑alkylamines, N-methyl-N-nitroso-1-octanamine, -decanamine, ‑dodecanamine, and ‑tetradecanamine

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of Proposition 65¹. The Carcinogen Identification Committee (CIC) of OEHHA’s Science Advisory Board serves as the State’s qualified experts and renders an opinion about whether a chemical has been clearly shown to cause cancer². The chemicals identified by the CIC are added to the Proposition 65 list.

OEHHA has selected the chemicals below for the CIC’s review for possible listing under Proposition 65. OEHHA is initiating the development of hazard identification materials on these chemicals.

Chemicals Selected for Preparation of Cancer Hazard Identification Materials

Chemicals	CAS No.
N-Methyl-N-nitroso-1-alkylamines	---
N-Methyl-N-nitroso-1-octanamine	34423-54-6
N-Methyl-N-nitroso-1-decanamine	75881-22-0
N-Methyl-N-nitroso-1-dodecanamine	55090-44-3
N-Methyl-N-nitroso-1-tetradecanamine	75881-20-8

These chemicals were selected using the procedure described in the document: “Process for Prioritizing Chemicals for Consideration under Proposition 65 by the State’s Qualified Experts.”

OEHHA selected these chemicals from those prioritized by the CIC in 2011.

Hazard identification materials for these chemicals will be presented at a future CIC meeting for Committee consideration of possible listings of the chemicals under Proposition 65.

By this notice, OEHHA is giving the public an opportunity to provide information relevant to the assessment of the evidence of carcinogenicity for N‑methyl‑N‑nitroso‑1‑alkylamines, N-methyl-N-nitroso-1-octanamine, -decanamine, ‑dodecanamine, and ‑tetradecanamine. Relevant information includes but is not limited to:

cancer bioassays
cancer epidemiological studies
genotoxicity testing
other pertinent data on:
- pharmacokinetics
- biomarkers
- effects on biochemical and physiological processes in humans

Interested parties or members of the public wishing to provide such information should send it to the address given below.

The publication of this notice marks the start of a 60-day data call-in period, ending on Tuesday, May 21, 2013. The information received during this period will be reviewed and considered by OEHHA as it prepares the cancer hazard identification documents on these chemicals.

Hazard identification documents are made available to the public for comment prior to the CIC’s consideration of the chemical for possible listing. Their availability for comment will be announced in the California Regulatory Notice Register and on OEHHA’s website. Public comments received on these documents are sent to the CIC for its consideration prior to the CIC meeting at which the chemicals will be considered for listing. The time, date, location, and agenda of the CIC meeting where a chemical will be considered for listing will also be published in the California Regulatory Notice Register and posted on OEHHA’s website.

We encourage you to submit relevant information responsive to this request in electronic form, rather than in paper form. Submissions transmitted by e-mail should be addressed to P65Public.Comments@oehha.ca.gov. Please include “N-Methyl-N-nitroso-1-alkylamines” in the subject line. Submissions in paper form may be mailed, faxed, or delivered in person to the addresses below:

Mailing Address: Proposition 65
Office of Environmental Health Hazard Assessment
P.O. Box 4010, MS-19B
Sacramento, California 95812-4010
Fax:(916) 323-2265
Street Address:1001 I Street
Sacramento, California 95814

In order to be considered at this point in the process, the relevant information must be received at OEHHA by 5:00 p.m. on Tuesday, May 21, 2013.