Request for Information on the Carcinogenic Hazards of: Clomiphene and its salts, 2,6-Dimethyl-N-nitrosomorpholine, Haloperidol, Tris(1,3-dichloro-2-propyl) phosphate (TDCPP)

Announcement of Chemicals Selected by OEHHA for Consideration for Listing by the Carcinogen Identification Committee and Request for Relevant Information on the Carcinogenic Hazards of These Chemicals: Clomiphene and its salts, 2,6-Dimethyl-N-nitrosomorpholine, Haloperidol, Tris(1,3-dichloro-2-propyl) phosphate (TDCPP)

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of Proposition 65¹.  The Carcinogen Identification Committee (CIC) of OEHHA’s Science Advisory Board serves as the State’s qualified experts and renders an opinion about whether a chemical has been clearly shown to cause cancer.  The chemicals identified by the CIC are added to the Proposition 65 list. 

OEHHA has selected the four chemicals below for the CIC’s review for possible listing under Proposition 65.  OEHHA is initiating the development of hazard identification materials on these chemicals. 

Chemicals Selected for Preparation of Cancer Hazard Identification Materials

These chemicals were selected using the procedure described in a 2004 document entitled: “Process for Prioritizing Chemicals for Consideration under Proposition 65 by the State’s Qualified Experts.”

OEHHA selected these chemicals from those prioritized by the CIC in 2009 and 2010. 

Hazard identification materials for each of the four chemicals will be presented at future meetings of the CIC for Committee review for possible listing under Proposition 65. 

By this notice, OEHHA is giving the public an opportunity to provide information relevant to the assessment of the evidence of carcinogenicity for any of the chemicals shown above.  Relevant information includes but is not limited to: 

• cancer bioassays
• cancer epidemiological studies
• genotoxicity testing
• other pertinent data on:
  • pharmacokinetics,
  • biomarkers
  • effects on biochemical and physiological processes in humans. 

Interested parties or members of the public wishing to provide such information should send it to the address given below. 

The publication of this notice marks the start of a 60-day data call-in period, ending on Tuesday, April 12, 2011.  The information received during this period will be reviewed and considered by OEHHA as it prepares the cancer hazard identification materials on these chemicals. 

Hazard identification materials are made available to the public for comment prior to the CIC’s consideration of the chemical for possible listing.  The availability of hazard identification materials will be announced in the California Regulatory Notice Register and on OEHHA’s website.  The time, date, location, and agenda of the CIC meeting where a chemical will be considered for listing will be published in the California Regulatory Notice Register and posted on OEHHA’s website. 

We encourage you to submit relevant information on these chemicals in electronic form, rather than in paper form.  Submissions transmitted by e-mail should be addressed to P65Public.Comments@oehha.ca.gov.  Submissions in paper form may be mailed, faxed, or delivered in person to the addresses below:

Mailing Address:    
Office of Environmental Health Hazard Assessment
P.O. Box 4010, MS-19B
Sacramento, California 95812-4010
Fax: (916) 323-8803
Street Address:1001 I Street
Sacramento, California 95814

In order to be considered at this point in the process, the relevant information must be received at OEHHA by 5:00 p.m. on Tuesday, April 12, 2011. 

Comment Period

• Comment Period - Request for Information on the Carcinogenic Hazards of: Clomiphene and its salts, 2,6-Dimethyl-N-nitrosomorpholine, Haloperidol, Tris(1,3-dichloro-2-propyl) phosphate (TDCPP)

Chemical Reference

• Tris(1,3-dichloro-2-propyl) Phosphate (TDCPP)
• 2,6-Dimethyl-N-nitrosomorpholine (DMNM)
• Haloperidol
• Clomiphene and its salts

Meeting Announcements/Information

• September 21 and 22, 2010 Meeting of the Carcinogen Identification Committee
• May 29, 2009 Carcinogen Identification Committee Meeting

Related Notices

• Prioritization: Chemicals for Consultation by the May 29, 2009 Carcinogen Identification Committee

  Mar 5, 2009
• Prioritization: 27 Chemicals Identified for Consultation with the Proposition 65 Carcinogen Identification Committee

  Jul 9, 2010
• Availability of Final Data Summaries and Priorities for 33 Chemicals With Respect to Their Potential to Cause Cancer

  Sep 19, 1997
• tris(1,3-dichloro-2-propyl) phosphate (TDCPP) Listed Effective October 28, 2011 as Known to the State to Cause Cancer

  Oct 28, 2011
• Request for Information on the Carcinogenic Hazards of: Clomiphene and its salts, 2,6-Dimethyl-N-nitrosomorpholine, Haloperidol, Tris(1,3-dichloro-2-propyl) phosphate (TDCPP)

  Feb 11, 2011
• C.I. Disperse Yellow 3 and 2,6-dimethyl-N-nitrosomorpholine (DMNM) Listed Effective February 8, 2013 as Known to the State of California to Cause Cancer

  Feb 8, 2013

Footnotes and References

¹Safe Drinking Water and Toxic Enforcement Act of 1986, Health and Safety Code section 25249.5 et seq.