Hexamethylene Diisocyanate (Monomer)

CAS Number

822-06-0

Synonym

1,6-Diisocyanatohexane, 1,6-hexane diisocyanate, HMDI

Date Added

09/06/2019

HDI Monomer

Cancer Potency Information

Latest Criteria:	Reference Exposure Levels

Air

Acute RELs

Acute REL (μg/m3):	0.3
Species:	Rodents
Acute REL Toxicologic Endpoint:	Nasal epithelium lesions
Acute REL Target Organs:	Respiratory system
Last Acute REL Revision:	09/06/2019
Acute Reference Exposure Levels Comments:	Notice of Adoption of Reference Exposure Levels for Hexamethylene Diisocyanate (Monomer and Polydiisocyanates)

8-Hour RELs

8-Hour Inhalation REL (μg/m3):	0.06
Last 8-Hour REL Revision:	09/06/2019
8-Hour Reference Exposure Levels Comments:	Notice of Adoption of Reference Exposure Levels for Hexamethylene Diisocyanate (Monomer and Polydiisocyanates)

Chronic REL

Chronic Inhalation REL (μg/m3):	0.03
Chronic Target Organs:	Respiratory system
Human Data:	Yes
Chronic Toxicologic Endpoint:	HDI-induced asthma; accelerated decline in lung function
Last Chronic REL Revision:	09/06/2019
Chronic Reference Exposure Levels Comments:	Notice of Adoption of Reference Exposure Levels for Hexamethylene Diisocyanate (Monomer and Polydiisocyanates)