Understanding and Applying Read-Across for Human Health Risk Assessment
CalEPA Office of Environmental Health Hazard Assessment
WORKSHOP & WEBCAST
May 2, 2019
9:00 Welcome & Introductory Remarks
Lauren Zeise, Director, Office of Environmental Health Hazard Assessment
SESSION I
SINGLE CHEMICAL READ-ACROSS APPROACHES IN PREDICTING HAZARD, POTENCY, AND RISK: WHERE ARE WE NOW?
Moderator: Ivan Rusyn, Texas A&M University
9:10 Read-Across in US EPA Provisional Peer-Reviewed Toxicity Values Assessments
Jason Lambert, US Environmental Protection Agency (US EPA)
9:35 NTP Read-Across in the Report on Carcinogens: Haloacetic Acids
Gloria Jahnke, National Toxicology Program (NTP)
10:00 Understanding Chemical and Mechanistic Classes: IARC Approach
Vince Cogliano, US EPA
10:15 Panel Discussion
10:40 Break
SESSION II
READ-ACROSS PRINCIPLES IN TESTING AND ASSESSING PFAS CHEMICALS
Moderator: Weihsueh Chiu, Texas A&M University
11:00 PFAS Chemicals in California: The Current Need for Characterization
Julie Henderson, Deputy Secretary for Heath and Public Policy, CalEPA
11:10 PFAS Prioritization for Targeted Testing
Grace Patlewicz, US EPA
11:50 NTP Approach to Testing of PFAS Chemicals
Mike DeVito, NTP
12:30 Break for Lunch
1:30 Approaches to Hazard and Dose Response Assessment
Jason Lambert, US EPA
2:10 Panel and Audience Discussion
Panelists:
Session II & III Speakers
Michele La Merrill, University of California, Davis
Martyn Smith, University of California, Berkeley
Tracey Woodruff, University of California, San Francisco
3:00 Break
SESSION III
USE OF COMPUTATIONAL METHODS IN READ-ACROSS
Moderator: Melanie Marty, OEHHA
3:15 CTV & Integrating it into Read-Across
Jessica Wignall, ICF
3:40 Use of GenRA to Assist in Read-Across
Grace Patlewicz, US EPA National Center for Computational Toxicology
4:10 Navigating ChemMaps
Nicole Kleinstreuer, National Institute for Environmental Health Sciences
4:40 Discussion
4:55 Closing Remarks