Agenda for the May 2017 Domoic Acid Workshop "Evaluating the State of the Science and Implications for Human Toxicity"
Domoic Acid Workshop
On May 4, 2017, OEHHA and UC Davis co-hosted a domoic acid workshop at the UC Davis Buehler Alumni Center to discuss the state of the science and implications for human toxicity. Representatives from academia, government, and non-profit organizations participated in scientific lectures, panel discussions, and audience question and answer sessions on topics related to the potential health impacts of domoic acid exposure.
Discussion topics included:
- Effects reported in marine mammals and rodents, and their relevance to human health
- Chronic, low-level domoic acid exposure in humans
- Pharmacokinetics and understanding the human dose
- Endpoints relevant to Autism Spectrum Disorders
For more information on domoic acid, visit OEHHA’s marine biotoxin page.
Evaluating the State of the Science
and Implications for Human Toxicity
AGENDA
9:00 – 9:20 Opening Remarks: Workshop Goal and Purpose
Office of Environmental Health Hazard Assessment (OEHHA) and UC Davis
9:20 – 9:40 Prince Edward Island: 1987 Domoic Acid Event
Andrew Tasker, University of Prince Edward Island
SESSION I Moderator: Susan Klasing, OEHHA
9:40 – 10:10 What Marine Mammals Tell Us about Potential Human Toxicity Endpoints
Frances Gulland, Marine Mammal Center (Sausalito)
10:10 – 10:25 BREAK
10:25 – 10:55 Chronic, Low-level Domoic Acid Exposure in Humans: the CoASTAL Cohort
Lynn Grattan, University of Maryland
10:55 – 11:25 Disposition, Pharmacokinetics and Understanding the Human Dose
John Ramsdell, National Oceanic and Atmospheric Administration
11:25 – 12:00 Discussion Panel
Irva Hertz-Picciotto, UC Davis (Facilitator); Elaine Faustman, University of Washington (UW); Melissa Miller, CA Department of Fish and Wildlife; Session I speakers; Audience Q&A
12:00 – 1:00 LUNCH
SESSION II Moderator: Shannon Murphy, OEHHA
1:00 – 1:30 Domoic Acid Experiments in Mice: Exposure, Pharmacokinetics, Pathways of Interest, and Endpoints
Elaine Faustman, University of Washington
1:30 – 2:00 Domoic Acid Experiments in Rats: Exposure, Neurodevelopmental Toxicity, and Behavioral Teratology
Tracy Doucette, University of Prince Edward Island
2:00 – 2:30 Domoic Acid Experiments in Mice and Endpoints Relevant to Autism Spectrum Disorders
Garet Lahvis, Oregon Health Sciences University
2:30 – 3:05 Discussion Panel
Pam Lein, UC Davis (Facilitator); Isaac Pessah, UC Davis; John Ramsdell, NOAA; Session II speakers; Audience Q&A
3:05 – 3:20 BREAK
SESSION III Moderator: Gina Solomon, California Environmental Protection Agency
3:20 – 3:45 Putting it all Together: Models, Endpoints and Dose-Response
Andrew Tasker, University of Prince Edward Island
3:45 – 4:45 Discussion Panel: What do the Data and Models Tell Us about Human Toxicity?
Irva Hertz-Picciotto, UC Davis (Facilitator); Elaine Faustman, UW; Gina Solomon, CalEPA; Andrew Tasker, UPEI; Audience Q&A
4:45 – 5:00 Closing Remarks
Lauren Zeise, OEHHA
