Propylene Oxide
CAS Number
75-56-9Synonym
AI3-07541; Caswell No. 713A; Epoxypropane; 1,2-epoxypropane; Methyl ethylene oxide; Methyloxirane; NCI-C50099; Propene oxide; Propylene epoxide; Propyleneoxide; EPA Pesticide Code: 042501
Occurrence/Use
Fumigant (almonds, pistachios), preparation of biological samples, herbicide component; production of polyurethane plastics, polyester resins, solvent, preservatives, de-icing fluid, liquid for electronic cigarettes. Has been used as racing fuel and glow fuel. Component of tobacco smoke
Cancer Potency Information
| Inhalation Unit Risk (μg/cubic meter)-1: | 3.7 E-6 |
|---|---|
| Inhalation Slope Factor (mg/kg-day)-1: | 1.3 E-2 |
| Oral Slope Factor (mg/kg-day)-1: | 2.4 E-1 |
| Comments/References: |
OEHHA 2009. Air Toxics Hot Spots Program Technical Support Document for Cancer Potencies. Appendix B. Chemical-specific summaries of the information used to derive unit risk and cancer potency values. Updated 2011.
US EPA 1990. IRIS Database: Propylene oxide. |
Air
Acute RELs
| Acute REL (μg/m3): | 3100 |
|---|---|
| Species: | Mouse |
| Acute REL Toxicologic Endpoint: | Reproductive/ development (reduced fertility and teratogenic effects in rats), respiratory and eye irritation |
| Acute REL Target Organs: | Reproductive/ development, respiratory system, eyes |
| Severity: | Severe |
| Last Acute REL Revision: | 1999 |
| Acute Reference Exposure Levels Comments: |
OEHHA 2008. Technical Supporting Document for Noncancer RELs, Appendix D2. |
Chronic REL
| Chronic Inhalation REL (μg/m3): | 30 |
|---|---|
| Chronic Target Organs: | Respiratory system |
| Human Data: | No |
| Last Chronic REL Revision: | 2000 |
| Chronic Reference Exposure Levels Comments: |
OEHHA 2008. Technical Supporting Document for Noncancer RELs, Appendix D3
|
Proposition 65
Chemical Status
| Cancer: | Currently listed |
|---|
Cancer
| Listed as causing : | Listed as causing: Cancer |
|---|---|
| Date of Listing: |