Nickel and Nickel Compounds
CAS Number
7440-02-0Synonym
Nickel 200; Nickel 201; Nickel 205; Nickel 207; Carbonyl nickel powder; Ni
Occurrence/Use
Alloys (low-alloy steels, stainless steel, copper and brass, permanent magnets, electrical resistance alloys), electroplated protective coatings, electroformed coatings, alkaline storage batteries, fuel cell electrodes, catalyst for methanation of fuel gases and hydrogenation of vegetable oils; component of tobacco smoke
Child-Specific Reference Dose
| Child-specific refence dose (chRD) (mg/kg-day, unless noted): | 1.1 E-2 |
|---|---|
| Last chRD revision: | 12/2005 |
| chRD Comments: |
Soil Screening
| Last CHHSL revision: | 1/2005 |
|---|---|
| CHHSL Comments: |
For chemical-specific screening levels for use in assessing contaminated sites, please see HHRA Note 3 (DTSC HERO). https://www.dtsc.ca.gov/assessingrisk/humanrisk2.cfm |
Cancer Potency Information
| Inhalation Unit Risk (μg/cubic meter)-1: | 2.6 E-4 |
|---|---|
| Inhalation Slope Factor (mg/kg-day)-1: | 9.1 E-1 |
| Comments/References: |
OEHHA 2009. Air Toxics Hot Spots Program Technical Support Document for Cancer Potencies. Appendix B. Chemical-specific summaries of the information used to derive unit risk and cancer potency values. Updated 2011. |
Air
Acute RELs
| Acute REL (μg/m3): | 0.2 |
|---|---|
| Species: | Mouse |
| Acute REL Toxicologic Endpoint: | Depressed antibody response |
| Acute REL Target Organs: | Immune system |
| Last Acute REL Revision: | 2012 |
| Acute Reference Exposure Levels Comments: |
Inhalation concentrations as micrograms Ni/m3. |
8-Hour RELs
| 8-Hour Inhalation REL (μg/m3): | 0.06 |
|---|---|
| Last 8-Hour REL Revision: | 2012 |
| 8-Hour Reference Exposure Levels Comments: |
Inhalation concentrations as micrograms Ni/m3. |
Chronic REL
| Chronic Inhalation REL (μg/m3): | 0.014 (inhalation); 11 μg/kg BW-day (oral) |
|---|---|
| Chronic Target Organs: | Inhalation: Respiratory system, hematologic system. Oral: Development |
| Human Data: | No |
| Last Chronic REL Revision: | 2012 |
| Chronic Reference Exposure Levels Comments: |
Inhalation concentrations as micrograms Ni/m3; oral dose as micrograms Ni/kg-day. |
Proposition 65
Chemical Status
| Cancer: | Currently listed |
|---|
Cancer
| Listed as causing : | Listed as causing: Cancer |
|---|---|
| Date of Listing: |
Comments
Public notices related to this chemical
- Chemicals Selected by OEHHA for Consideration for Listing by the DART Identification Committee and Request for Relevant Information on the Reproductive Toxicity Hazards of: n-Hexane, Nickel and Nickel Compounds, PFOA and PFOS and their salts
- Chemical Listed Effective May 7, 2004 as known to the State of California to Cause Cancer: Nickel Compounds
- Clarification of Chemical Listing of Nickel and Certain Nickel Compounds and Request for Comment on Proposed Listing of Nickel Compounds as Known to Cause Cancer
Water
California Public Health Goals Data
| Health Risk Category: | Developmental toxicity (increased neonatal deaths) |
|---|---|
| Public Health Goal (mg/L): | 0.012 |
| Public Health Goal - Download: | nickel82001.pdf |
| Cancer Risk at PHG: | n/a |
| MCL value (mg/L): | 0.1 |
| Cancer Risk at MCL: | n/a |
| Last PHG Revision : | 2001 |
| California PHG Comments: |
Not considered an oral carcinogen; PHG based on reproductive toxicity. PHG applies to soluble nickel compounds. |
'Nickel acetate', 'Nickel carbonate', 'Nickel carbonyl', 'Nickel compounds', 'Nickel hydroxide', 'Nickelocene', 'Nickel oxide', 'Nickel refinery dust from the pyrometallurgical process', and 'Nickel subsulfide' listed separately.