Chloroform
CAS Number
67-66-3Synonym
Formyl trichloride; Methane trichloride; Methenyl chloride; Methenyl trichloride; NCI-C02686; TCM; Trichloromethane; EPA Pesticide Code: 020701
Occurrence/Use
Solvent, reagent; production of dyes, pesticides; chemical intermediate; component of tobacco smoke. Formerly used as inhalational anaesthetic until 1976.
Cancer Potency Information
| Inhalation Unit Risk (μg/cubic meter)-1: | 5.3 E-6 |
|---|---|
| Inhalation Slope Factor (mg/kg-day)-1: | 0.019 |
| Oral Slope Factor (mg/kg-day)-1: | 0.031 |
| Comments/References: |
OEHHA 2009. Air Toxics Hot Spots Program Technical Support Document for Cancer Potencies. Appendix B. Chemical-specific summaries of the information used to derive unit risk and cancer potency values. Updated 2011. ARB - 1990 Proposed Identification of Chloroform as a Toxic Air Contaminant (pages 8-14 - 8-17) |
Air
Acute RELs
| Acute REL (μg/m3): | 150 |
|---|---|
| Species: | Rat |
| Acute REL Toxicologic Endpoint: | Reproductive/ development; dizziness, respiratory depression |
| Acute REL Target Organs: | Reproductive/ development, nervous system, respiratory system |
| Severity: | Severe |
| Last Acute REL Revision: | 1999 |
| Acute Reference Exposure Levels Comments: |
OEHHA 2008. Technical Supporting Document for Noncancer RELs, Appendix D2. |
Chronic REL
| Chronic Inhalation REL (μg/m3): | 300 |
|---|---|
| Chronic Target Organs: | Alimentary system (liver), kidney, development |
| Human Data: | No |
| Last Chronic REL Revision: | 2000 |
| Chronic Reference Exposure Levels Comments: |
OEHHA 2008. Technical Supporting Document for Noncancer RELs, Appendix D3
|
Proposition 65
Chemical Status
| Cancer: | Currently listed |
|---|---|
| Reproductive Toxicity : | Currently listed |
Cancer
| Listed as causing : | Listed as causing: Cancer |
|---|---|
| Date of Listing: |
Reproductive Toxicity
| Listed as causing: | Developmental Toxicity | Developmental Toxicity |
|---|---|
| Date of Listing: | |
| Basis for Listing : | State's Qualified Experts |
Safe Harbor Levels
| Cancer |
Documents, Presentations, and Publications
| Reproductive Toxicity: |
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Public notices related to this chemical
- Notice of Proposed Rulemaking Title 27, California Code of Regulations Amendment To Section 25805 Specific Regulatory Levels: Chemicals Causing Reproductive Toxicity Chloroform
- Augmentation and Clarification of Record for Proposed Regulation - Chloroform
- Decision Not to Proceed - Proposed Amendment to Section 25805 Specific Regulatory Levels Chemicals Causing Reproductive Toxicity: Chloroform
- Notice to Change the Basis for Listing for Chloroform as Known to the State of California to Cause Reproductive Toxicity
Water
California Public Health Goals Data
| Health Risk Category: | Hepatotoxicity (liver), nephrotoxicity |
|---|---|
| Public Health Goal - Download: | thmsphgdraft110819.pdf |
| California PHG Comments: |