Chloroform
CAS Number
67-66-3Synonym
Formyl trichloride; Methane trichloride; Methenyl chloride; Methenyl trichloride; NCI-C02686; TCM; Trichloromethane; EPA Pesticide Code: 020701
Occurrence/Use
Solvent, reagent; production of dyes, pesticides; chemical intermediate; component of tobacco smoke. Formerly used as inhalational anaesthetic until 1976.
| Inhalation Unit Risk (μg/cubic meter)-1: |
5.3 E-6
|
|---|---|
| Inhalation Slope Factor (mg/kg-day)-1: |
0.019
|
| Oral Slope Factor (mg/kg-day)-1: |
0.031
|
| Comments/References: |
OEHHA 2009. Air Toxics Hot Spots Program Technical Support Document for Cancer Potencies. Appendix B. Chemical-specific summaries of the information used to derive unit risk and cancer potency values. Updated 2011. ARB - 1990 Proposed Identification of Chloroform as a Toxic Air Contaminant (pages 8-14 - 8-17) |
Air
| Acute REL (μg/m3): |
150
|
|---|---|
| Species: |
Rat
|
| Acute REL Toxicologic Endpoint: |
Reproductive/ development; dizziness, respiratory depression
|
| Acute REL Target Organs: |
Reproductive/ development, nervous system, respiratory system
|
| Severity: |
Severe
|
| Last Acute REL Revision: |
1999
|
| Acute Reference Exposure Levels Comments: |
| Chronic Inhalation REL (μg/m3): |
300
|
|---|---|
| Chronic Target Organs: |
Alimentary system (liver), kidney, development
|
| Human Data: |
No
|
| Last Chronic REL Revision: |
2000
|
| Chronic Reference Exposure Levels Comments: |
Proposition 65
| Cancer: |
Currently listed
|
|---|---|
| Reproductive Toxicity: |
Currently listed
|
| Listed for: |
Cancer
|
|---|---|
| Date of Listing: |
10/01/1987
|
| Basis for Listing: |
State's Qualified Experts
|
| Listed for: |
Developmental Toxicity
|
|---|---|
| Developmental Toxicity | |
| Date of Listing: |
08/07/2009
|
| Basis for Listing: |
State's Qualified Experts
|
| Cancer | |
| No Significant Risk Level (NSRL) - Oral: |
20 µg/day
|
|---|---|
| No Significant Risk Level (NSRL) - Inhalation: |
40 µg/day
|
| Reproductive Toxicity: |
|---|
Public notices related to this chemical:
- Notice of Proposed Rulemaking Title 27, California Code of Regulations Amendment To Section 25805 Specific Regulatory Levels: Chemicals Causing Reproductive Toxicity Chloroform
- Augmentation and Clarification of Record for Proposed Regulation - Chloroform
- Decision Not to Proceed - Proposed Amendment to Section 25805 Specific Regulatory Levels Chemicals Causing Reproductive Toxicity: Chloroform
- Notice to Change the Basis for Listing for Chloroform as Known to the State of California to Cause Reproductive Toxicity
Water
| Health Risk Category: |
Hepatotoxicity (liver), nephrotoxicity
|
|---|---|
| Public Health Goal - Download: | |
| California PHG Comments: |