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Estimating Workplace Air and Worker Blood Lead Concentration using an Updated PBPK Model

The Office of Environmental Health Hazard Assessment (OEHHA) is pleased to submit the final report, titled Estimating Workplace Air and Worker Blood Lead Concentration using an Updated Physiologically-based Pharmacokinetic (PBPK) Model, to the Occupational Lead Poisoning Prevention Program (OLPPP) of the California Department of Public Health. The report was prepared for OLPPP under contract numbers 09-13020 and 11-0852 to better understand workplace exposures.  This report covers the first two tasks of the contract, to model the air lead/blood lead level (BLL) relationship and to model the time to decline to lower BLLs from higher BLLs.

The last task of the contract, to model the relationship between BLL and the amount of lead on surfaces in the workplace, was left in its draft state. This was subsequent to our September 2011 submittal of a draft modeling report, titled PBPK Modeling of Workplace Lead Exposure, and OLPPP’s request that OEHHA focus future efforts on modeling BLL decline instead of lead on workplace surfaces.

Note: An updated version of the report, Estimating Workplace Air and Worker Blood Lead Concentration using an Updated Physiologically-based Pharmacokinetic (PBPK) Model, was posted on December 10, 2014.

If you have any questions about the final report, please contact the primary author, Dr. Kathleen Vork, at kathleen.vork@oehha.ca.gov.

 

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