Ethylene Glycol (Ingested) Listed as a Reproductive Toxicant

Effective June 19, 2015, the Office of Environmental Health Hazard Assessment (OEHHA) is adding ethylene glycol (ingested) (CAS No. 107-21-1) to the list of chemicals known to the state to cause reproductive toxicity for purposes of Proposition 651

The listing of this chemical is based on formal identification by the National Toxicology Program (NTP), an authoritative body2, in a final report by the NTP Center for the Evaluation of Risks to Human Reproduction (CERHR), that ethylene glycol causes reproductive toxicity (developmental endpoint) at high oral doses.  The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 27, Cal. Code of Regs., section 25306.

The documentation supporting OEHHA’s determination that the criteria for administrative listing have been satisfied for ethylene glycol is included in the Notice of Intent to List posted on OEHHA’s website and published in the April 11, 2014 issue of the California Regulatory Notice Register (Register 2014, No. 15-Z.  OEHHA received seven public comments on the Notice of Intent to List.  The comments and OEHHA’s responses are posted with the Notice of Intent to List.

A complete, updated chemical list will be published in the California Regulatory Notice Register and is available on the OEHHA website.  In summary, ethylene glycol is being listed under Proposition 65 as known to the State to cause reproductive toxicity, as follows:



Toxicological Endpoints

Listing Mechanism*

Ethylene Glycol (ingested)


Developmental toxicity


Footnotes and References

* Listing mechanism:  AB – “authoritative bodies” mechanism (Title 27, Cal. Code of Regs., section 25306).

1 The Safe Drinking Water and Toxic Enforcement Act of 1986, Health and Safety Code section 25249.5 et seq.

2 See Health and Safety Code, section 25249.8(b) and Title 27, Code of Regs., section 25306.