Chemicals Proposed for Listing by the Labor Code Mechanism (Reproductive and Developmental Toxicants)

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The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is requesting comments as to whether the chemicals identified in the table below meet the requirements for listing under the Safe Drinking Water and Toxic Enforcement Act of 1986. The Act, commonly known as Proposition 65, is codified in Health and Safety Code section 25249.5 et seq. This action is being taken pursuant to Health and Safety Code section 25249.8(a).

Chemicals Proposed for Listing Via the Labor Code

Chemical CAS No. Endpoint Reference
Tert-Amyl methyl ether 994-05-8 Developmental ACGIH (2009)
n-Butyl glycidyl ether 2426-08-6 Male reproduction ACGIH (2009)
Carbaryl 63-25-2

Male reproduction
Developmental

ACGIH (2009)
Chloroform 67-66-3 Developmental ACGIH (2009)
2-Chloropropionic acid 598-78-7 Male reproduction ACGIH (2009)
Dichloroacetic acid 79-43-6 Male reproduction ACGIH (2009)
Diglycidyl ether 2238-07-5 Male reproduction ACGIH (2009)
N,N-dimethylacetamide 127-19-5 Developmental ACGIH (2009)

Ethylene oxide

75-21-8

Male reproduction

Developmental1
29 CFR part 1910,
Subpart Z
Ethyl-tert-butyl ether 637-92-3 Male reproduction ACGIH (2009)
2-Ethylhexanoic acid 149-57-5 Developmental ACGIH (2009)
Methyl chloride 74-87-3 Male reproduction2 ACGIH (2009)
Methyl n-butyl ketone 591-78-6 Male reproduction ACGIH (2009)
p,p’-Oxybis(benzenesulfonyl hydrazide) 80-51-3 Developmental ACGIH (2009)
Phenyl glycidyl ether 122-60-1 Male reproduction ACGIH (2009)
Phenylphosphine 638-21-1 Developmental ACGIH (2009)
Toluene 108-88-3 Female reproduction2 ACGIH (2009)
1,3,5-Triglycidyl-s-triazinetrione 2541-62-9 Male reproduction ACGIH (2009)
4-Vinyl-cyclohexene 100-40-3

Male reproduction
Female reproduction

ACGIH (2009)

1Already on the Proposition 65 list on the basis of female reproductive toxicity
2Already on the Proposition 65 list on the basis of developmental toxicity

Background on listing by the Labor Code mechanism:  Health and Safety Code section 25249.8(a) incorporated certain provisions of the California Labor Code into Proposition 65. The law requires that certain substances identified as causing reproductive toxicity in 29 CFR part 1910, Subpart Z, Toxic and Hazardous Substances, Occupational Safety and Health Administration or in the Threshold Limit Values for Chemical Agents in the Work Environment, American Conference of Governmental Industrial Hygienists [ACGIH] (latest edition) be listed as known to cause reproductive toxicity under Proposition 65. As the lead agency for the implementation of Proposition 65, the OEHHA evaluates whether listing under Proposition 65 is required.

OEHHA’s determination:   In the case of all of the above-identified chemicals except ethylene oxide, the ACGIH Threshold Limit Value was established based solely or in part on a relevant reproductive or developmental effect.  In the case of ethylene oxide, Title 29 of the Code of Federal Regulations, section 1910, subpart Z, identifies the chemical as causing developmental and male reproductive toxicity.

Request for comment: OEHHA is requesting comments as to whether the chemicals identified above meet the requirements for listing as causing reproductive toxicity, as specified in Health and Safety Code section 25249.8(a).  Because these are ministerial listings, comments should be limited to the question whether the ACGIH has established a TLV for the chemical or substance that is based in whole or in part on a reproductive or developmental effect, or whether OSHA has identified the chemical as causing reproductive or developmental effects in Title 29, CFR section 1910, subpart Z.  Under this listing mechanism, OEHHA cannot consider scientific arguments concerning the weight or quality of the evidence and will not respond to such comments if they are submitted.

OEHHA must receive comments by 5:00 p.m. on Monday, July 13, 2009.  A public workshop will be held only upon request.  Such request must be made in writing to the address below within 10 days from the publication of this notice.  We encourage you to submit comments in electronic form, rather than in paper form.  Comments transmitted by e-mail should be addressed to p65.questions@oehha.ca.gov.  Comments submitted in paper form may be mailed, faxed, or delivered in person to the address below.  A public workshop will be held only upon request.  Such request must be made in writing to the address below within 10 days from the publication of this notice:

Mailing Address:
Office of Environmental Health Hazard Assessment
P.O. Box 4010, MS-19B
Sacramento, California 95812-4010
Fax: (916) 323-8803
Street Address: 1001 I Street
Sacramento, California 95814

If you have any questions, please contact the Proposition 65 Office at (916) 445-6900.

Public Comments