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Prioritization: Chemicals for Consultation by the Carcinogen Identification Committee

This notice announces the beginning of a 60-day public comment period on the 39 chemicals listed below.  These chemicals will be discussed at the October 2011 meeting of the Proposition 65 Carcinogen Identification Committee (CIC).  The CIC is the state’s qualified experts on carcinogenicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65).  The CIC’s October meeting is scheduled for Wednesday and Thursday, October 12 and 13, 2011.  The CIC will provide the Office of Environmental Health Hazard Assessment (OEHHA) with advice on the prioritization of these 39 chemicals for possible preparation of hazard identification materials.  At a later date, OEHHA will select chemicals for preparation of hazard identification materials and announce those decisions in a separate notice.  No listing decisions will be made for these chemicals at the October 12 and 13 meetings. 

OEHHA is the lead agency for the implementation of Proposition 65.  OEHHA has screened several hundred chemicals in the OEHHA tracking database for evidence of cancer hazard as well as potential human exposure in California.  The initial screening follows the procedure described in the 2004 “Process for Prioritizing Chemicals for Consideration under Proposition 65 by the State’s Qualified Experts.”

OEHHA applied both a human and animal data screen to all of the chemicals in the OEHHA tracking database.  These screens were discussed at the November 17, 2007 and November 5, 2008 meetings of the CIC.  OEHHA conducted a preliminary toxicological evaluation for the chemicals that passed the two screens.  Based on this preliminary evaluation, OEHHA identified the 39 chemicals listed below for committee discussion, advice and possible preparation of hazard identification materials for consideration at future CIC meetings. 

Download the document Prioritization: Chemicals Identified for Consultation with the Carcinogen Identification Committee.

The 39 chemicals are:

  • Abacavir and Its Salts
  • Acetaminophen
    and Appendix A
  • Bisphenol A
  • Butyl Benzyl Phthalate
  • Butylated Hydroxytoluene
  • C.I. Disperse Yellow 3
  • Chloroalkyl Ethers
  • Chloropicrin
  • Clodinafop-Propargyl
  • Coumarin
  • Dapsone
  • Dibenzanthracenes and Dibenz[a,c]anthracene
  • 3,3'-Dichlorobenzidine-Based Compounds Metabolized to 3,3'-Dichlorobenzidine
  • 2,4-Dichlorophenoxyacetic acid (2,4-D) and Its Salts and Esters
  • Dicloran
  • Dinitroaniline Pesticides and Prodiamine and Trifluralin
  • Entecavir
  • Flonicamid
  • Fluazinam
  • Hexythiazox
  • Hydralazine and Its Salts
  • Isophosphamide
  • Metofluthrin
  • Mixtures Containing Pentabromochlorocyclohexane
  • N-Methyl-N-Nitroso-1-Alkylamines and N-Methyl-N-Nitroso-1-Octanamine, N-Methyl-N-Nitroso-1-Decanamine, N-Methyl-N-Nitroso-1-Dodecanamine, and N-Methyl-N-Nitroso-1-Tetradecanamine
  • N-Nitroso-N-Methylaniline
  • N-Methylpyrrolidone
  • 6-Nitrobenzimidazole
  • Pentachloronitrobenzene
  • Pimecrolimus and Tacrolimus
  • Pivalolactone
  • Pyraflufen Ethyl
  • Raloxifen and Its Salts
  • Stavudine
  • Thiophanate Methyl
  • Topoisomerase II Inhibitors
  • Triazole Antifugal Agents
  • 2,4,6-Trimethylaniline and Its Salts
  • Tris(2-Ethylhexyl) Phosphate

The CIC meeting will be held in the Sierra Hearing Room at the Cal/EPA Headquarters building, 1001 I Street, Sacramento, California.  The meetings will begin each day at 10:00 a.m. and will last until 5:00 p.m. on Wednesday and until all business is conducted or until 5:00 p.m. on Thursday.  The agenda for the two-day meeting will be provided in a future public notice published in advance of the meeting.

Copies of the summaries of available scientific information on the chemicals and related attachments are available on OEHHA’s web site or may be requested by calling (916) 445-6900. 
Interested parties may provide comment on the extent of the scientific evidence pertaining to the selection of any of these chemicals for possible preparation of hazard identification materials.  OEHHA must receive comments and any supporting documentation by 5:00 p.m. on Tuesday, September 20, 2011.  We encourage you to submit comments in electronic form, rather than in paper form.  Comments transmitted by e-mail should be addressed to coshita@oehha.ca.gov.  Comments submitted in paper form may be mailed, faxed, or delivered in person to the addresses below:

Mailing Address: Ms. Cynthia Oshita
Office of Environmental Health Hazard Assessment
P.O. Box 4010, MS-19B
Sacramento, California 95812-4010
Fax: (916) 323-8803
Street Address: 1001 I Street
Sacramento, California 95814

OEHHA will organize and index the comments received and forward the information to the CIC members prior to the meeting on October 12 and 13.  

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