Chemicals Delisted December 13, 2013 as Known to the State of California to Cause Reproductive Toxicity: tert‑amyl methyl ether, 2-ethylhexanoic acid, ethyl-tert-butyl ether, p,p’‑oxybis(benzenesulfonyl hydrazide) and 1,3,5-triglycidyl-s-triazinetrione

Effective December 13, 2013, the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is removing tert‑amyl methyl ether, 2-ethylhexanoic acid, ethyl-tert-butyl ether, p,p’‑oxybis(benzenesulfonyl hydrazide) and 1,3,5-triglycidyl-s-triazinetrione from the list of chemicals known to the State to cause reproductive toxicity for purposes of Proposition 65¹.  Tert-amyl methyl ether and ethyl-tert-butyl ether were added to the list on December 18, 2009 and 2-ethylhexanoic acid, p,p’‑oxybis(benzenesulfonyl hydrazide) and 1,3,5-triglycidyl-s-triazinetrione were added to the list on August 7, 2009. 

These five chemicals were originally added to the Proposition 65 list as causing reproductive toxicity pursuant to Labor Code Section 6382(d), which is incorporated by reference in Health and Safety Code Section 25249.8(a).  Based on changes to certain federal regulations that affect the bases for the original listings, OEHHA referred these chemicals to the Developmental and Reproductive Toxicant Identification Committee (DART IC) for reconsideration.  In its official capacity as the “state’s qualified experts” at a public meeting held on November 21, 2013, the DART IC determined that the five chemicals have not been clearly shown, through scientifically valid testing according to generally accepted principles, to cause reproductive toxicity and should be removed from the list.  Regulations governing the listing of chemicals by the DART IC are set out in Title 27, California Code of Regulations, section 25305(b)(1).

A complete, updated chemical list is published in this issue of the California Regulatory Notice Register and is available on the OEHHA website.

Chemical Reference

• 1,3,5-triglycidyl-s-triazinetrione
• 2-Ethylhexanoic acid
• p,p’‑oxybis(benzenesulfonyl hydrazide)
• Tert-Amyl methyl ether
• Ethyl-tert-butyl ether

Related Notices

• Chemicals Listed Effective August 7, 2009 as Known to the State of California to Cause Cancer or Reproductive Toxicity

  Aug 7, 2009
• Chemicals Listed Effective December 18, 2009 as Known to the State of California to Cause Cancer or Reproductive Toxicity: wood dust, zidovudine (AZT), Tert-Amyl methyl ether (TAME) and ethyl-tert-butyl ether (EBTE)

  Dec 18, 2009
• Hazard Identification Materials to Support Reconsideration of Listing: 9 Chemicals Listed Via the Labor Code as Known to the State of California to Cause Reproductive Toxicity

  Sep 20, 2013

Footnotes and References

¹ The Safe Drinking Water and Toxic Enforcement Act of 1986, Health and Safety Code section 25249.5 et seq.