Proposition 65 Administrative Listing Listed Effective November 4, 2011 as Known to the State of California to Cause Cancer: five chemicalsFollow this link to download the current Proposition 65 list that includes estrogen-progestogen (combined) used as menopausal therapy, etoposide (CAS No. 33419-42-0), etoposide in combination with cisplatin and bleomycin, methyl isobutyl ketone (CAS No. 108-10-1) and MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) (CAS No. 113803-47-7)
If you would like to sort the list by CAS number or date, please download the list as an Excel document. You can then sort the list by date, CAS number, or chemical name using MS Excel. The Excel document also includes the listing mechanism for each chemical listing and the safe harbor level, if one has been adopted. A hyperlink is provided for those chemicals for which the basis for listing documentation is available electronically. A hyperlink is provided for those safe harbor levels for which the risk assessment documentation is available electronically.
The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding five chemicals – estrogen-progestogen (combined) used as menopausal therapy, etoposide (CAS No. 33419-42-0), etoposide in combination with cisplatin and bleomycin, methyl isobutyl ketone (CAS No. 108-10-1) and MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) (CAS No. 113803-47-7) -- to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 651). The listing of these five chemicals is effective November 4, 2011.
Health and Safety Code section 25249.8(a) requires that certain substances identified by the International Agency for Research on Cancer (IARC), as described in Labor Code section 6382(b)(1) and (d), be included on the Proposition 65 list as causing cancer. Labor Code section 6382(b)(1) references substances identified as human or animal carcinogens by IARC, and Labor Code section 6382(d) references substances identified as carcinogens or potential carcinogens by IARC.
The basis for the listing of the five chemicals was described in a public notice published in the September 16, 2011, issue of the California Regulatory Notice Register (Register 2011, No. 37-Z). The title of the notice was “Notice of Intent to List Chemicals by the Labor Code Mechanism: Estrogen-progestogen (combined) used as menopausal therapy, etoposide, etoposide in combination with cisplatin and bleomycin, methyl isobutyl ketone, MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture)”. The publication of the notice initiated a 30-day public comment period that closed on October 17, 2011.
A complete, updated Proposition 65 list is published elsewhere in this issue of the California Regulatory Notice Register and is available on the OEHHA website at http://www.oehha.ca.gov/prop65.html.
Chemical |
CAS No. |
Endpoint |
Listing Mechanism2 |
Estrogen–progestogen (combined) used as menopausal therapy |
-- |
Cancer |
LC |
Etoposide |
33419-42-0 |
Cancer |
LC |
Etoposide in combination with cisplatin and bleomycin |
-- |
Cancer |
LC |
Methyl isobutyl ketone |
108-10-1 |
Cancer |
LC |
MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) |
113803-47-7 |
Cancer |
LC |
1Health and Safety Code, section 25249.5 et seq.
2Listing mechanism: LC – “Labor Code” mechanism (Labor Code sections 6382(b)(1) and (d))
