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The California Environmental Protection Agency's
Office of Environmental Health Hazard Assessment (OEHHA) is the
lead agency for the implementation of the Safe Drinking Water
and Toxic Enforcement Act of 1986 (Proposition 65). As the lead
agency, OEHHA is removing saccharin from the list of chemicals
known to the state to cause cancer, for purposes of Proposition
Saccharin [CAS No. 81-07-2] was originally added
to the Proposition 65 list on October 1, 1989. This chemical was
added to the Proposition 65 list as a result of the issuance of
a judicial decision enforcing Labor Code Section 6382(b)(1) and
(d) which are incorporated by reference as Proposition 65 listing
provisions pursuant to Health and Safety Code Section 25249.8(b).
Labor Code Section 6382(b)(1) requires inclusion of substances
listed as human or animal carcinogens by the International Agency
for Research on Cancer (IARC). Labor Code Section 6382(d) requires
the inclusion of chemicals identified as carcinogens or potential
carcinogens by IARC or the National Toxicology Program (NTP).
Saccharin was identified by IARC and NTP as causing cancer.
In 2000, NTP released its Ninth Report on Carcinogens
in which it removed saccharin [CAS No. 81 07-2] from the list
of substances "reasonably anticipated to be a human carcinogen."
In 1999, IARC issued a monograph on "Saccharin and its Salts",
Volume 73, in which it reclassified saccharin and its salts as
"not classifiable as to their carcinogenicity to humans (Group
3)" and concluded that there was "inadequate evidence
in experimental animals for the carcinogenicity of saccharin (acid
form)." Since saccharin was added to the Proposition 65 list
by operation of law based on the Labor Code Section incorporation
by reference of chemicals identified as known or potential carcinogens
by IARC or NTP, the removal of saccharin from designation as such
by both of these entities means that saccharin should be removed
from the Proposition 65 list. Therefore, saccharin will be delisted
as a chemical known to the state to cause cancer effective April
A complete, updated chemical list denoting saccharin
in strikeout is published elsewhere in
this issue of the California Regulatory Notice Register.
The chemical delisted as known to the state to cause cancer effective
April 6, 2001 is:
this link to download a copy of this notice
Download the April 6, 2001 list in PDF format
View the April 6, 2001 Proposition 65 List.
Download the April 6, 2001 list as a MS Excel spreadsheet
You will need the free program Adobe Acrobat Reader to view or
print PDF files
For questions regarding Proposition 65, please contact the Cynthia
Oshita in the Proposition 65 Implementation Program
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