Request for Relevant Information on the Developmental and Reproductive Toxicity of: Bisphenol-A, Chlorpyrifos, Chromium, DDE, Sulfur dioxide

Announcement of Chemicals Selected by OEHHA for Consideration for Listing by the Developmental and Reproductive Toxicant Identification Committee and Request for Relevant Information on the Developmental and Reproductive Toxicity of These Chemicals: Bisphenol-A, Chlorpyrifos, Chromium, DDE, Sulfur dioxide

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986* (Proposition 65).  The Developmental and Reproductive Toxicant Identification Committee (DARTIC) of OEHHA’s Science Advisory Board serves as the State’s qualified experts for rendering an opinion whether a chemical has been clearly shown through scientifically valid testing according to generally accepted principles to cause reproductive toxicity.  The chemicals identified by the DARTIC are added to the Proposition 65 list, which must be updated annually. 

OEHHA has selected five chemicals for the Committee’s review for possible listing under Proposition 65 and is initiating the development of hazard identification materials on these chemicals.  The chemicals are listed in Table 1 below. 

Table 1. Chemicals Selected for Preparation of Reproductive Toxicity Hazard Identification Materials and Review for Possible Listing by the Developmental and Reproductive Toxicant Identification Committee

These chemicals were selected using the procedure described in the document entitled: “Process for Prioritizing Chemicals for Consideration under Proposition 65 by the State’s Qualified Experts,” adopted in 2004, and available on the Internet at www.oehha.ca.gov. 

Following this prioritization process, OEHHA identified eight chemicals through application of an epidemiology data screen and a preliminary compilation and review of the toxicological evidence related to their reproductive toxicity.  On this basis OEHHA proposed these chemicals for Committee review and consultation.  On September 7, 2007, OEHHA released for public comment the eight chemicals proposed for Committee review, along with a summary of the available scientific information on each chemical’s potential to cause reproductive toxicity.  These materials were also provided to the Committee and made available on OEHHA’s Web site.  The Committee met to consider these materials at a public meeting on December 10, 2007.  In considerationof the DARTIC’s recommendations and the totality of the discussion at the meeting, OEHHA will begin preparation of hazard identification materials for the five chemicals identified in Table 1.  These hazard identification materials will be presented at a subsequent meeting for Committee review for possible listing of the chemical under Proposition 65.  More information on the DARTIC’s recommendations is available on OEHHA’s Web site at www.oehha.ca.gov.

By this notice, OEHHA is providing the public an opportunity to provide information relevant to the assessment of the evidence of developmental and reproductive toxicity for any of the chemicals listed in Table 1.  Interested parties or members of the public wishing to provide such information should send it to the address given below. 

The publication of this notice marks the start of a 60-day data call-in period.  This period will end on Tuesday, March 18, 2008.  The information received during this data call-in period will be reviewed and considered by OEHHA as it prepares the reproductive toxicity hazard identification materials on these chemicals.  This request for information is the next step in the process described in the 2004 prioritization procedure. 

Notification of the availability of the hazard identification materials and of the time, date, location, and agenda of the meetings of the Developmental and Reproductive Identification Committee where these chemicals will be considered will be provided in subsequent notices published in the California Regulatory Notice Register and will also be posted on OEHHA’s website.  It is anticipated that the hazard identification materials will be made available for a 60-day comment period prior to the Committee meetings at which these chemicals will be considered.

Relevant information on these chemicals should be submitted to:

the Proposition 65 Office
Office of Environmental Health Hazard Assessment
Proposition 65 Implementation
P.O. Box 4010
1001 I Street, 19th Floor
Sacramento, California 95812-4010
FAX:  (916) 323-8803
Or via e-mail to sam.delson@oehha.ca.gov

It is requested that all hard-copy materials be submitted in triplicate.

Submissions may also be delivered in person or by courier to the above address.  In order to be considered, the relevant information must be received at OEHHA (if delivered in person or sent by FAX) by 5:00 p.m. on Tuesday, March 18, 2008.

Comment Period

• Comment Period - Information on the Developmental and Reproductive Toxicity of: Bisphenol-A, Chlorpyrifos, Chromium, DDE, Sulfur dioxide
• Extension of Comment Period - Bisphenol-A
• 2009 Developmental and Reproductive Toxicant Identification Committee meeting

Chemical Reference

• Chlorpyrifos
• Bisphenol A (BPA)
• Sulfur Dioxide
• Chromium (hexavalent compounds)
• DDE (Dichlorodiphenyldichloroethylene)

Meeting Announcements/Information

• November 20, 2008 Developmental and Reproductive Toxicant Identification Committee Meeting
• 2009 Developmental and Reproductive Toxicant Identification Committee meeting

Related Notices

• Request for Relevant Information on the Developmental and Reproductive Toxicity of: Bromodichloromethane, Caffeine and Methylisocyanate

  Jun 27, 2008
• Availability of Hazard Identification Materials for Sulfur Dioxide and Announcement of the May 12 and 13, 2011 Developmental and Reproductive Toxicant Identification Committee Meeting

  Feb 25, 2011
• Hazard ID Materials for Hexavalent Chromium and Chlorpyrifos, Submission of Relevant Studies for Particulate Matter and Total Trihalomethanes

  Sep 5, 2008
• Additional Information on Chlorpyrifos

  Nov 3, 2008
• Additional Information on Chlorpyrifos - Toxicity Profile

  Nov 3, 2008
• Petitions For and Against Listing BPA Pursuant to the Authoritative Bodies Mechanism

  Oct 8, 2009
• Hazard Identification Materials for Bisphenol A (developmental and reproductive toxicity)

  May 1, 2009
• Request for Information on a Chemical Being Considered for Listing by the Authoritative Bodies Mechanism: Bisphenol-A

  Feb 12, 2010
• Hazard Identification Materials for Consideration of the Female Reproductive Toxicity of Bisphenol-A

  Feb 20, 2015
• Proposed Amendment to Section 25805 Specific Regulatory Levels: Chemicals Causing Reproductive Toxicity Bisphenol-A

  Jan 25, 2013
• Prioritization: Chemicals for Consultation by the Carcinogen Identification Committee

  Jul 22, 2011
• Notice of Proposed Rulemaking Title 27, California Code of Regulations Amendment to Section 25805 Specific Regulatory Levels: Chemicals Causing Reproductive Toxicity Sulfur Dioxide

  Jun 28, 2012
• Synopsis, Follow-up Actions and Slide Presentations from the December 10, 2007 Developmental and Reproductive Toxicant Identification Committee Meeting

  Jan 11, 2008
• Chemicals Listed Effective December 19, 2008 As Known To The State Of California To Cause Cancer Or Reproductive Toxicity: 2,4,6-Trinitrotoluene (TNT) (CAS No. 118-96-7) and Chromium (hexavalent compounds)

  Dec 18, 2008

Footnotes and References

*Health and Safety Code section 25249.5 et seq.