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Green Chemistry

California Green Chemistry Workshop

Indicators of Ecotoxicity Hazards and Exposure Potential
May 10-11, 2010

David Brower Center, Richard and Rhoda Goldman Theatre
2151 Allston Way, Berkeley 94704

Download the agenda as a pdf file here.

Green chemistry is the design of chemical products and processes that reduce or eliminate the use or generation of hazardous substances. A key component is product reformulation to replace hazardous chemicals with less hazardous ones. A major obstacle is the lack of data on exposure, environmental effects and human toxicity in determining the safety of a chemical.

A 2009 Green Chemistry law (Senate Bill 509) requires Cal/EPA’s Office of Environmental Health Hazard Assessment to evaluate and specify the hazard traits, toxicological endpoints and other relevant data to be included in California’s Toxics Information Clearinghouse. The Clearinghouse will be constructed by the Cal/EPA’s Department of Toxic Substances Control. Hazard traits for ecotoxicity and exposure potential will be included.

This workshop explores indicators of ecotoxicity and exposure potential for use when evaluating chemicals. A March 2010 workshop explored indicators of human health hazard.

Workshop sponsors: Office of Environmental Health Hazard Assessment, UCLA Law and Environmental Health Sustainable Technology Policy Program, UC’s Berkeley Center for Green Chemistry, UC Center for Occupational and Environmental Health, UC Toxic Substances Research and Teaching Program.

To register for the workshop, please send your name, email address and affiliation to:

Monday, May 10, 2010

Indicators of Human and Ecosystem Exposure Potential

1:00 - Welcome
Joan Denton, Director, Office of Environmental Health Hazard Assessment

Melanie Marty
, Office of Environmental Health Hazard Assessment

1:15 - Physical-Chemical Properties in Parsimonious Models of Human and Environmental Exposure Potential
Tom McKone
, UC Berkeley School of Public Health and Lawrence Livermore National Laboratory

1:55 Persistence and Bioaccumulation Measurements
Akos Kokai
, UC Berkeley School of Public Health

2:20 Predicting Persistence, Bioaccumulation, and Other Indicators of Exposure Potential from Chemical Structure
Derek Muir
, Environment Canada
Phil Howard, SRC Environmental Science Center

3:00 Break

3:15 Critical Parameters Determining Indoor Exposure to Consumer Products
Bill Nazaroff
, UC Berkeley Department of Civil and Environmental Engineering

3:55 Panel Discussion

Moderator: Lauren Zeise, Office of Environmental Health Hazard Assessment

Which assays, indicators and models are sufficiently well developed to indicate exposure potential?

5:00 Adjourn for the Day

Tuesday, May 11, 2010

Screens and Emerging Tests Indicative of Ecological Hazard

9:00 Moderator: Megan Schwarzman, UC Berkeley School of Public Health and Center for Green Chemistry

9:05 Assessing the Ecological Risk of Toxic Chemicals: A Framework for Testing in the 21st Century
Gary Ankley
, US Environmental Protection Agency, Environmental Effects Research Laboratory

9:50 Emerging ‘Omic and Other Screens for Ecotoxicity Assessment
Chris Vulpe
, UC Berkeley Department of Nutrition Science and Toxicology

10:35 Q& A

10:45 Break

11:00 Indicators of Endocrine Disruption from Xenobiotics in Amphibians
Tyrone Hayes
, UC Berkeley Department of Integrative Biology

11:30 Is a Revision of the Bioaccumulation Paradigm Needed? ABC Efflux Transporters as Determinants of Accumulation and Toxicity
David Epel
, Stanford University, Hopkins Marine Station

12:00 Chemical Impacts on Neurotransmitters, Behavior and Reproduction in Fish
Dan Schlenk
, UC Riverside Department of Environmental Sciences

12:30 Q & A

12:45 Lunch

2:00 Panel Discussion
Which assays and models are sufficiently well developed to indicate potential for ecotoxicity effects?

Moderator: Melanie Marty, Office of Environmental Health Hazard Assessment

George Alexeeff, Office of Environmental Health Hazard Assessment
Gary Ankley, US Environmental Protection Agency
David Epel, Stanford University
Tyrone Hayes, UC Berkeley
Dan Schlenk, UC Riverside
Patti TenBrook, US Environmental Protection Agency, Region 9
Chris Vulpe, UC Berkeley

4:30 Workshop Wrap-up
George Alexeef
f, Office of Environmental Health Hazard Assessment

4:45 Adjourn

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