Availability of Draft Data Summaries and Draft Priorities for Chemicals With Respect to Their Potential to Cause Cancer
The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA), as lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65), has developed a procedure for prioritizing chemicals for consideration under Proposition 65 by the "State’s qualified experts". Two committees of the Science Advisory Board (SAB), known as the Carcinogen Identification Committee, and the Developmental and Reproductive Toxicant (DART) Identification Committee, serve as the State’s qualified experts for rendering an opinion as to whether a chemical is known to the State to cause
The procedure used by OEHHA to identify, prioritize and select candidate chemicals for evaluation by the SAB Committees is described in, "Procedure for Prioritizing Candidate Chemicals for Consideration Under Proposition 65 by the State’s Qualified Experts," May 1997. In accordance with this procedure, prioritized chemicals with a final priority of High Carcinogenicity Concern are assigned to the Candidate List, from which chemicals will be chosen for the preparation of hazard identification documents, and subsequent evaluation by the Carcinogen Identification Committee. All chemicals not assigned a final "high" level of carcinogenicity concern are assigned to Category II. In a slight change from previous releases, where draft priorities of Medium High, Medium, and Low Carcinogenicity Concern were stated explicitly in the data summaries, here draft priorities are identified as either "High" Carcinogenicity Concern, or "Not High" enough to merit placement on the Candidate List. We are implementing this change following the recognition that considerable resources have been expended by both the interested public and the State in the course of providing and responding to comments not pertinent to the placement of chemicals on or off the Candidate List. The main purpose of this phase of the prioritization process is to decide which chemicals should appear on the Candidate List; many of the comments received on previous releases focused on refining the priority of chemicals within Category II. We welcome comments from the public
Download the draft data summaries in the download section below.
With this notice we are announcing the release of draft data summaries and draft priorities concerning the potential for the chemicals indicated below to cause cancer. This notice initiates a 60-day public comment period. These 60 chemicals were selected for prioritization as described in OEHHA’s Notice to Interested Parties: Results of the Second Round Pilot Random Selection of the Chemicals Eligible for Prioritization For Consideration of Carcinogenicity Evaluation, published in the California Regulatory Notice Register on April 3, 1998. The chemicals and their draft priorities are as follows:
|
Name of Chemical |
CAS No. |
|---|---|
|
On Candidate List due to High Carcinogenicity Concern |
|
|
allyl isovalerate |
2835-39-4 |
|
4-bis(2-hydroxyethyl)amino-2-(5-nitro-2-thienyl)-quinazoline |
33372-39-3 |
|
bleomycin |
11056-06-7 |
|
1-butylhydrazine hydrochloride |
56795-65-4 |
|
carboxymethylnitrosourea |
60391-92-6 |
|
3-chloromethylpyridine hydrochloride |
6959-48-4 |
|
chrysoidine |
532-82-1 |
|
N,N'-diethylthiourea |
105-55-5 |
|
3,3'-dimethoxybenzidine-4,4'-diisocyanate |
91-93-0 |
|
dimethyldiazene-1-oxide (methylazoxymethane / azoxymethane) |
25843-45-2 |
|
estradiol mustard |
22966-79-6 |
|
N'-ethyl-N-methyl-N-nitrosourea |
72479-13-1 |
|
N'-ethyl-N-nitrosobutylamine |
4549-44-4 |
|
4-ethylsulfonylnaphthalene-1-sulfonamide |
842-00-2 |
|
hexachlorobutadiene |
87-68-3 |
|
ICRF-159 |
21416-87-5 |
|
isophosphamide |
3778-73-2 |
|
lovastatin |
75330-75-5 |
|
N-(2-methoxyethyl)-N-nitrosourea |
108278-70-2 |
|
3'-methyl-4-dimethylaminoazobenzene |
55-80-1 |
|
methylphenidate and its hydrochloride (Ritalin) |
113-45-1 |
|
4-methylquinoline |
491-35-0 |
|
MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) |
77439-76-0 |
|
6-nitrobenzimidazole |
94-52-0 |
|
N-nitrosomethyl-N-heptylamine |
16338-99-1 |
|
N-nitroso-N-pentylurea (N-amyl-N-nitrosurea) |
10589-74-9 |
|
petasitenine |
60102-37-6 |
|
phenelzine and its acid salts |
156-51-4 |
|
pivalolactone |
1955-45-9 |
|
pyrrolizidine alkaloids which are metabolized to dehydroretronecine or dehydroheliotridine |
--- |
|
sesamol |
533-31-3 |
|
styrene |
100-42-5 |
|
tetrachlorvinphos |
22248-79-9 |
|
2,4,6-trimethylaniline and its hydrochloride (aminomesitylene) |
88-05-1 |
|
Name of Chemical |
CAS No. |
|---|---|
|
Category II |
|
|
2-amino-5-nitrothiazole |
121-66-4 |
|
11-aminoundecanoic acid |
2432-99-7 |
|
antipyrine (phenazone) |
60-80-0 |
|
p-benzoquinone dioxime |
105-11-3 |
|
C.I. acid blue 9 and its salts |
2650-18-2 |
|
C.I. acid red 51 |
16423-68-0 |
|
chlorinated paraffins (C23; 43% chlorine) |
108171-27-3 |
|
4-chloro-4'-aminodiphenyl ether |
101-79-1 |
|
4-chloro-m-phenlyenediamine |
5131-60-2 |
|
dibromomannitol |
488-41-5 |
|
diclofop-methyl |
51338-27-3 |
|
diltiazem |
42399-41-7 |
|
FD&C blue no. 2 |
860-22-0 |
|
malathion |
121-75-5 |
|
6-methoxy-2-nitronaphtho[1,8-bc]pyran |
10502-39-9 |
|
mexacarbate |
315-18-4 |
|
omeprazole |
73590-58-6 |
|
tocopherol mix (E-mix 80) |
1406-66-2 |
|
triadimenol |
55219-65-3 |
|
tribenuron methyl |
101200-48-0 |
|
trimethylthiourea |
2489-77-2 |
|
tris(2-ethylhexyl)phosphate (trioctyl phosphate) |
78-42-2 |
|
troysan polyphase (IPBC) |
55406-53-6 |
|
Inadequate Data to establish level of concern |
|
|
1-butanol (n-butanol, n-butyl alcohol) |
71-36-3 |
|
2-bromo-2-methylpropane (tert-butyl bromide) |
507-19-7 |
|
Postponed |
|
|
bis(4-chlorophenyl)sulfone (p,p'-dichlorophenylsulfone) |
80-07-9 |
OEHHA also announces that a public workshop to receive external scientific peer review and public comments on the draft data summaries and draft priority assignments for these chemicals will be held on Friday, April 9, 1999. The workshop will commence at 10:00 a.m. in Conference Room A, Elihu Harris State Building, 1515 Clay Street, Oakland California, and will last until all business has
OEHHA is committed to public participation and external scientific peer review in its implementation of Proposition 65, and welcomes public input. The draft data summaries and draft priority assignments for these chemicals are available from the Proposition 65 Implementation Office at the address and telephone number indicated below, or from the Internet at the following address:
Written comments may be submitted in triplicate to:
Cynthia Oshita
Office of Environmental Health Hazard Assessment
301 Capitol Mall, 2nd Floor
Sacramento, California 95814
FAX (916) 327-1097
(916) 445-6900
In order to be considered, comments must be postmarked (if sent by mail) or received at OEHHA (if delivered in person or sent by FAX) by 5 p.m. Tuesday, April 20, 1999.
